CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020136
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein fuzzy homolog 
Protein Synonyms/Alias
  
Gene Name
 FUZ 
Gene Synonyms/Alias
 FY 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
351PEPGPPEKTEDEVYQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MGEEGTGGTV HLLCLAASSG VPLFCRSSRG GAPARQQLPF SVIGSLNGVH MFGQNLEVQL 60
SSARTENTTV VWKSFHDSIT LIVLSSEVGI SELRLERLLQ MVFGAMVLLV GLEELTNIRN 120
VERLKKDLRA SYCLIDSFLG DSELIGDLTQ CVDCVIPPEG SLLQEALSGF AEAAGTTFVS 180
LVVSGRVVAA TEGWWRLGTP EAVLLPWLVG SLPPQTARDY PVYLPHGSPT VPHRLLTLTL 240
LPSLELCLLC GPSPPLSQLY PQLLERWWQP LLDPLRACLP LGPRALPSGF PLHTDILGLL 300
LLHLELKRCL FTVEPLGDKE PSPEQRRRLL RNFYTLVTST HFPPEPGPPE KTEDEVYQAQ 360
LPRACYLVLG TEEPGTGVRL VALQLGLRRL LLLLSPQSPT HGLRSLATHT LHALTPLL 418 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0010172; P:embryonic body morphogenesis; ISS:UniProtKB.
 GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
 GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.
 GO:0001942; P:hair follicle development; ISS:UniProtKB.
 GO:0001843; P:neural tube closure; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB. 
Interpro
 IPR026069; Fuzzy. 
Pfam
  
SMART
  
PROSITE
  
PRINTS