Tag | Content |
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CPLM ID | CPLM-016366 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF187 |
Protein Synonyms/Alias | RING domain AP1 coactivator 1; RACO-1; RING finger protein 187 |
Gene Name | Rnf187 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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141 | GSVEIMRKDLNDARD | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 (By similarity). |
Sequence Annotation | ZN_FING 12 53 RING-type. CROSSLNK 195 195 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 224 224 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 225 225 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Complete proteome; Cytoplasm; Isopeptide bond; Ligase; Metal-binding; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 236 AA |
Protein Sequence | MALPAGPADA ICALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA 60 VEPSRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD GDPLCSACRM AAGPEPPEWE 120 PRWRKALRGK ENKGSVEIMR KDLNDARDLH GQAESAAAVW KGHVMDRRKK ALTDYKKLRA 180 FFVEEEEHFL QEAEKDEGAS EDDELADPAD RFRSLLQAVS ELEKKHRNLG LSMLLQ 236 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. GO:0051865; P:protein autoubiquitination; ISS:UniProtKB. GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. |
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