UniProt Accession

 SERC_YEAST; P33330; D6W2P0 

Genbank Protein ID

 L20917; U19714; Z75092; BK006948 

Genbank Nucleotide ID

 AAA20886.1; AAA85703.1; CAA99393.1; DAA10956.1 

Protein Name

 Phosphoserine aminotransferase 

Protein Synonyms/Alias

 PSAT; Phosphohydroxythreonine aminotransferase 

Gene Name

 SER1 

Gene Synonyms/Alias

 SERC; YOR184W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
122	QKSFEEAKRLHVPAE	ubiquitination	[1]
348	GLDDQFLKEAAARHL	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity). 

Sequence Annotation

 REGION 80 81 Pyridoxal phosphate binding (By
 REGION 271 272 Pyridoxal phosphate binding (By
 BINDING 46 46 L-glutamate (By similarity).
 BINDING 113 113 Pyridoxal phosphate (By similarity).
 BINDING 170 170 Pyridoxal phosphate (By similarity).
 BINDING 194 194 Pyridoxal phosphate (By similarity).
 BINDING 217 217 Pyridoxal phosphate (By similarity).
 MOD_RES 20 20 Phosphothreonine.
 MOD_RES 112 112 Phosphoserine.
 MOD_RES 218 218 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Amino-acid biosynthesis; Aminotransferase; Complete proteome; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Serine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004648; F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity; IMP:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006564; P:L-serine biosynthetic process; IMP:SGD.
 GO:0009113; P:purine nucleobase biosynthetic process; IMP:SGD. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR020578; Aminotrans_V_PyrdxlP_BS.
 IPR022278; Pser_aminoTfrase.
 IPR003248; Pser_aminoTfrase_subgr.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

 PS00595; AA_TRANSFER_CLASS_5 

PRINTS