CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone morphogenetic protein 6 
Protein Synonyms/Alias
 BMP-6; VG-1-related protein; VG-1-R; VGR-1 
Gene Name
 BMP6 
Gene Synonyms/Alias
 VGR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
409DYNSSELKTACRKHEubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Induces cartilage and bone formation. 
Sequence Annotation
 CARBOHYD 241 241 N-linked (GlcNAc...) (Potential).
 CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
 CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
 CARBOHYD 404 404 N-linked (GlcNAc...) (Potential).
 CARBOHYD 454 454 N-linked (GlcNAc...) (Potential).
 DISULFID 412 478 By similarity.
 DISULFID 441 510 By similarity.
 DISULFID 445 512 By similarity.
 DISULFID 477 477 Interchain (By similarity).  
Keyword
 3D-structure; Chondrogenesis; Cleavage on pair of basic residues; Complete proteome; Cytokine; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Growth factor; Osteogenesis; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP 60
QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP 120
RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH 180
PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF 240
NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA 300
SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV 360
AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS 420
FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP 480
TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH 513 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0031988; C:membrane-bounded vesicle; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
 GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0001654; P:eye development; IEA:Compara.
 GO:0040007; P:growth; IEA:InterPro.
 GO:0006955; P:immune response; IMP:BHF-UCL.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0032349; P:positive regulation of aldosterone biosynthetic process; IDA:UniProtKB.
 GO:0030501; P:positive regulation of bone mineralization; IDA:BHF-UCL.
 GO:2000105; P:positive regulation of DNA-dependent DNA replication; NAS:BHF-UCL.
 GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:BHF-UCL.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IDA:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
 GO:0050714; P:positive regulation of protein secretion; NAS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0060395; P:SMAD protein signal transduction; IDA:UniProtKB.
 GO:0003323; P:type B pancreatic cell development; IDA:BHF-UCL. 
Interpro
 IPR001839; TGF-b_C.
 IPR001111; TGF-b_N.
 IPR015615; TGF-beta-rel.
 IPR017948; TGFb_CS. 
Pfam
 PF00019; TGF_beta
 PF00688; TGFb_propeptide 
SMART
 SM00204; TGFB 
PROSITE
 PS00250; TGF_BETA_1
 PS51362; TGF_BETA_2 
PRINTS