UniProt Accession

 I3L2J8_HUMAN; I3L2J8 

Genbank Protein ID

 AC027601 

Genbank Nucleotide ID

  

Protein Name

 5-azacytidine-induced protein 1 

Protein Synonyms/Alias

  

Gene Name

 AZI1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	PGSAATTKPIVRSVS	ubiquitination	[1]
57	TGSEQKRKVLEATGP	ubiquitination	[2]
110	EGSPSGKKRPASLST	ubiquitination	[1, 3]
122	LSTAPSEKGATWNVL	ubiquitination	[1, 2]
157	SPAGPRRKECTVALA	ubiquitination	[2, 3]
175	TANNRSNKGAVGNCV	ubiquitination	[2, 3]
200	SERAPPLKSSNQTAP	ubiquitination	[1, 2, 3, 4, 5]
214	PSLNNIIKAATCEGS	ubiquitination	[2, 3]
228	SESSGFGKLPKNVSS	ubiquitination	[2, 3, 5, 6]
231	SGFGKLPKNVSSATH	ubiquitination	[3]
254	STGLPRRKEVTEEEA	ubiquitination	[1, 4, 5]
300	LEHLLQAKREEQRQR	ubiquitination	[3]
320	LLDLHQQKEAARRKA	ubiquitination	[1, 2, 3, 4, 5, 7]
346	AIQELQQKRALRAQK	ubiquitination	[1, 3, 5]
353	KRALRAQKASTAERG	ubiquitination	[3]
510	DNLEKFGKLSAFPEP	ubiquitination	[1, 2, 3, 4, 5, 6, 8]
577	STSVMRLKLEVEEKK	ubiquitination	[3]
642	DQLIEDKKVLSEKCE	ubiquitination	[3]
647	DKKVLSEKCEAVVAE	ubiquitination	[3]
656	EAVVAELKQEDQRCT	ubiquitination	[3, 5, 6]
678	AQHELEIKKLKELMS	ubiquitination	[1, 4]
679	QHELEIKKLKELMSA	ubiquitination	[3]
681	ELEIKKLKELMSATE	ubiquitination	[3]
689	ELMSATEKARREKWI	ubiquitination	[3]
704	SEKTKKIKEVTVRGL	ubiquitination	[3]
717	GLEPEIQKLIARHKQ	ubiquitination	[2, 3, 5]
840	WEAGRTRKEEAWLLN	ubiquitination	[3]
919	QERCSELKGQLGEAE	ubiquitination	[3, 4, 5, 6]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1047 AA 

Protein Sequence

Gene Ontology

  

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS