CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001332
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit zeta 
Protein Synonyms/Alias
 TCP-1-zeta; CCT-zeta 
Gene Name
 CCT6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Oryctolagus cuniculus (Rabbit) 
NCBI Taxa ID
 9986 
Lysine Modification
Position
Peptide
Type
References
58AGDIKLTKDGNVLLHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. 
Sequence Annotation
 MOD_RES 199 199 N6-acetyllysine (By similarity).
 MOD_RES 365 365 N6-acetyllysine (By similarity).
 MOD_RES 377 377 N6-acetyllysine (By similarity).
 MOD_RES 388 388 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 60
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 120
EGFEAAKEKA LQVLEQIKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK 180
KQDEPIDLFM VEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE 240
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIVELKKK VCGDSDKGFV VINQKGIDPF 300
SLDALAKEGI VALRRAKRRN MERLTLACGG VPLNSLDDLN PDCLGHAGLV YEYTLGEEKF 360
TFIEKCNNPR SVTLLVKGPN KHTLTQIKDA IRDGLRAVKN AIDDGCVVPG AGAVEVAMAE 420
ALIKYKSSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIRTEH SESGQLVGVD 480
LNTGEPMVAA EVGIWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G 531 
Gene Ontology
 GO:0005832; C:chaperonin-containing T-complex; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051086; P:chaperone mediated protein folding independent of cofactor; TAS:Reactome. 
Interpro
 IPR012722; Chap_CCT_zeta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.