CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004142
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neural cell adhesion molecule 1 
Protein Synonyms/Alias
 N-CAM-1; NCAM-1; CD56 
Gene Name
 NCAM1 
Gene Synonyms/Alias
 NCAM 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
781EGKAAFSKDESKEPIubiquitination[1]
785AFSKDESKEPIVEVRubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 
Sequence Annotation
 DOMAIN 20 111 Ig-like C2-type 1.
 DOMAIN 116 205 Ig-like C2-type 2.
 DOMAIN 212 301 Ig-like C2-type 3.
 DOMAIN 308 413 Ig-like C2-type 4.
 DOMAIN 416 501 Ig-like C2-type 5.
 DOMAIN 506 605 Fibronectin type-III 1.
 DOMAIN 608 702 Fibronectin type-III 2.
 MOD_RES 784 784 Phosphoserine (By similarity).
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
 CARBOHYD 459 459 N-linked (GlcNAc...).
 CARBOHYD 488 488 N-linked (GlcNAc...) (Potential).
 DISULFID 41 96 Probable.
 DISULFID 139 189 Probable.
 DISULFID 235 287 Probable.
 DISULFID 329 395 Probable.
 DISULFID 436 489 Probable.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 858 AA 
Protein Sequence
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE 60
KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG EDGSESEATV NVKIFQKLMF 120
KNAPTPQEFR EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK 180
KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF 240
PEPTMSWTKD GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI 300
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS EEKASWTRPE 360
KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT IGQDSQSMYL EVQYAPKLQG 420
PVAVYTWEGN QVNITCEVFA YPSATISWFR DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS 480
ENDFGNYNCT AVNRIGQESL EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI 540
LKYKAEWRAV GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA 600
SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR ALSSEWKPEI 660
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTSGLS 720
TGAIVGILIV IFVLLLVVVD ITCYFLNKCG LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS 780
KDESKEPIVE VRTEEERTPN HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE 840
VKTVPNDATQ TKENESKA 858 
Gene Ontology
 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0030424; C:axon; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0034109; P:homotypic cell-cell adhesion; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0001928; P:regulation of exocyst assembly; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR009138; Neural_cell_adh. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS
 PR01838; NCAMFAMILY.