| Tag | Content |
|---|
| CPLM ID | CPLM-016940 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase trr |
Protein Synonyms/Alias | Lysine N-methyltransferase 2C; Trithorax-related protein |
Gene Name | trr |
Gene Synonyms/Alias | KMT2C; CG3848 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 15 | TSLGAAEKAKPERVA | acetylation | [1] | | 308 | TQLMVNAKKLSEVTQ | acetylation | [1] | | 422 | NTKIVATKVVSKKML | acetylation | [1] | | 426 | VATKVVSKKMLQLQQ | acetylation | [1] | | 633 | KTTMAQQKPKMITTT | acetylation | [1] | | 690 | TTANTPTKLSVSLAP | acetylation | [1] | | 742 | EEIGTPEKRLNANAT | acetylation | [1] | | 848 | VRAPSMGKVRSLEDQ | acetylation | [1] | | 1104 | ATTKIPFKPGEPQKR | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone- dependent manner causing H3 'Lys-4' trimethylation at ecdysone- inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow differentiation of the retinal epithelium, notably by activating expression of hh. |
Sequence Annotation | DOMAIN 2061 2121 FYR N-terminal.
DOMAIN 2122 2209 FYR C-terminal.
DOMAIN 2291 2407 SET.
DOMAIN 2415 2431 Post-SET.
MOTIF 801 805 LXXLL motif 1.
MOTIF 1652 1656 LXXLL motif 2.
MOTIF 2060 2064 LXXLL motif 3.
MOD_RES 1486 1486 Phosphothreonine.
MOD_RES 1488 1488 Phosphoserine.
MOD_RES 1490 1490 Phosphoserine. |
Keyword | Activator; Alternative splicing; Chromatin regulator; Chromosome; Complete proteome; Developmental protein; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2431 AA |
Protein Sequence | MNIPKVTTSL GAAEKAKPER VASVAAAAFN AVSLQKRSGD DTATPAEDPT RKKAKTELLL 60
GTGTAAPSLP AKASSTAPQQ LLYQRSGQQA KAQVKAASEP QDVETADGVW DARDQQIIVC 120
NFGSGTEMGA IKAEDADKQS EYRISTPRNS QSNPLLHRNT AFTSFTKKEG ASSSASSSSS 180
TASVISIEPS GSGQDHAENS GKSEDLDYVL MPASGADSST SVGNSTGTGT PAGTPIGATT 240
STIILNANNG TAGVSGAGTT TILTQKSGHT NYNIFNTTAT GSQTPTTTLL NRVNLHPKMK 300
TQLMVNAKKL SEVTQTTAKV SIGNKTISVP LLKPLMSASG AATAGGATIV ESKQLLQPGG 360
QVTTVMSAAQ QSGGQQVHPH VHSHAHHNFT KLIKRGPKNS GTIVSFSGLQ IKPANTKIVA 420
TKVVSKKMLQ LQQHQQQIQQ QQQLQQLQVT SGGGLAPPTG SIVTITTTNP SQTYAMVQDS 480
ATVGPAAHSE DDAPAPRKIT AYSENLQKIL NKSKSQESTG GPEEFTNINS VVIKPLDKNT 540
LNCPPSFNIF KQQQHSQAAQ SQSISAVGSG AGTPVTFTMA SGNASDLATT STVSVSAGTI 600
CINSPMMGTR PIISIQNKNI SLVLSKTTMA QQKPKMITTT TLSSQAALQM HHALIQDSSA 660
DKAGSSANSG SATSGASMQL KLTTANTPTK LSVSLAPDVV KLEEVGSESK AKLLVKQEAV 720
VKDSTGTPTS EERAEEIGTP EKRLNANATM TAINQVQNQS ANQIQMATST STASNPSTPN 780
PTVNATPMNN QRSAAEDNAL LKQLLQNNSS SHSLNQISIT SAHVGSASAS APLSARKVIN 840
VRAPSMGKVR SLEDQLARPV IPPVPTATQA AGSSSSSGSV ATSTTTTTVA SGGSSQQVAT 900
ASATALPVSA VAITTPGVGG EAKLEQKSDQ PAAIMQNQSQ NQAPPPPPPP QQQQQQQLHQ 960
PQQLQPSPHQ VKQTVQIVSK ETSFISGPVA AKTLVTEATS KPAELLPPPP YEMATAPISN 1020
VTISISTKQA APKELQMKPK AVAMSLPMEQ GDESLPEQAE PPLHSEQGAT AAGVAPHSGG 1080
PLVSAQWTNN HLEGGVATTK IPFKPGEPQK RKLPMHPQLD EKQIQQQAEI PISTSLPTTP 1140
TGQGTPDKVQ LISAIATYVK KSGVPNEAQP IQNQSQGQVQ MQAQMQATMQ GHLSGQMSGQ 1200
ISGHAAGQIP AQMHLQVQHQ LHMAVHPQQQ QQQLHQNQPQ NATIPLPVTG QGAVPIPVPT 1260
MESKAGDQRK RRKREVQKPR RTNLNAGQAG GALKDLTGPL PAGAMVQLAG MPPGTQYIQG 1320
AASGTGHVIT STGQGVTLGG VGASTGASSS PMLKKRVRKF SKVEEDHDAF TEKLLTHIRQ 1380
MQPLQVLEPH LNRNFHFLIG SNETSGGGSP ASMSSAASAG SSSAGGGKLK GGSRGWPLSR 1440
HLEGLEDCDG TVLGRYGRVN LPGIPSLYDS ERFGGSRGLV GGSARTRSPS PAESPGAEKM 1500
LPMSSIQNDF YDQEFSTHME RNPRERLVRH IGAVKDCNLE TVDLVESEGV AAWATLPRLT 1560
RYPGLILLNG NSRCHGRMSP VALPEDPLTM RFPVSPLLRS CGEELRKTQQ MELGMGPLGN 1620
NNNNNYQQKN QNVILALPAS ASENIAGVLR DLANLLHLAP ALTCKIIEDK IGNKLEDQFM 1680
NQDDEKHVDF KRPLSQVSHG HLRKILNGRR KLCRSCGNVV HATGLRVPRH SVPALEEQLP 1740
RLAQLMDMLP RKSVPPPFVY FCDRACFARF KWNGKDGQAE AASLLLQPAG GSAVKSSNGD 1800
SPGSFCASST APAEMVVKQE PEDEDEKTPS VPGNPTNIPA QRKCIVKCFS ADCFTTDSAP 1860
SGLELDGTAG AGTGAGPVNN TVWETETSGL QLEDTRQCVF CNQRGDGQAD GPSRLLNFDV 1920
DKWVHLNCAL WSNGVYETVS GALMNFQTAL QAGLSQACSA CHQPGATIKC FKSRCNSLYH 1980
LPCAIREECV FYKNKSVHCS VHGHAHAGIT MGAGAGATTG AGLGGSVADN ELSSLVVHRR 2040
VFVDRDENRQ VATVMHYSEL SNLLRVGNMT FLNVGQLLPH QLEAFHTPHY IYPIGYKVSR 2100
YYWCVRRPNR RCRYICSIAE AGCKPEFRIQ VQDAGDKEPE REFRGSSPSA VWQQILQPIT 2160
RLRKVHKWLQ LFPQHISGED LFGLTEPAIV RILESLPGIE TLTDYRFKYG RNPLLEFPLA 2220
INPSGAARTE PKQRQLLVWR KPHTQRTAGS CSTQRMANSA AIAGEVACPY SKQFVHSKSS 2280
QYKKMKQEWR NNVYLARSKI QGLGLYAARD IEKHTMIIEY IGEVIRTEVS EIREKQYESK 2340
NRGIYMFRLD EDRVVDATLS GGLARYINHS CNPNCVTEIV EVDRDVRIII FAKRKIYRGE 2400
ELSYDYKFDI EDESHKIPCA CGAPNCRKWM N 2431 |
Gene Ontology | GO:0044666; C:MLL3/4 complex; IDA:FlyBase. GO:0005700; C:polytene chromosome; IDA:FlyBase. GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:FlyBase. GO:0003713; F:transcription coactivator activity; IGI:FlyBase. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:1900114; P:positive regulation of histone H3-K9 trimethylation; IMP:FlyBase. GO:0045893; P:positive regulation of transcription, DNA-dependent; IGI:FlyBase. GO:0007458; P:progression of morphogenetic furrow involved in compound eye morphogenesis; IMP:FlyBase. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |