UniProt Accession

 F172A_HUMAN; Q8WUF8; B2R7C6; B4DJ14; B4DLG5; Q9H0U8 

Genbank Protein ID

 AL136630; AK295879; AK296986; AK312930; AC093268; AC099501; AC106818; AC108102; AC114980; AC117528; CH471084; BC020584 

Genbank Nucleotide ID

 CAB66565.1; BAG58676.1; BAG59527.1; BAG35773.1; EAW96012.1; AAH20584.1 

Protein Name

 Protein FAM172A 

Protein Synonyms/Alias

  

Gene Name

 FAM172A 

Gene Synonyms/Alias

 C5orf21 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	KEKTTALKDLLSRID	ubiquitination	[1, 2]
185	GTQIPFIKRAVAEGY	ubiquitination	[3]
333	VWHQEAGKTIREWMR	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 MOTIF 413 416 Prevents secretion from ER (Potential).  

Keyword

 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. 

Interpro

 IPR019154; Arb2_domain. 

Pfam

 PF09757; Arb2 

SMART

  

PROSITE

 PS00014; ER_TARGET 

PRINTS