| Tag | Content |
|---|
| CPLM ID | CPLM-013641 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Microtubule-associated tumor suppressor 1 homolog |
Protein Synonyms/Alias | AT2 receptor-binding protein; Angiotensin-II type 2 receptor-interacting protein; Coiled-coiled tumor suppressor gene 1 protein; Mitochondrial tumor suppressor 1 homolog |
Gene Name | Mtus1 |
Gene Synonyms/Alias | Atbp; Atip; Cctsg1; Kiaa1288; Mtsg1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 813 | TAFNSVEKGRQKNPR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. |
Sequence Annotation | MOD_RES 375 375 Phosphoserine.
MOD_RES 380 380 Phosphoserine.
MOD_RES 612 612 Phosphoserine.
MOD_RES 1164 1164 Phosphoserine (By similarity).
MOD_RES 1185 1185 Phosphoserine.
MOD_RES 1195 1195 Phosphoserine.
MOD_RES 1204 1204 Phosphoserine (By similarity).
MOD_RES 1206 1206 Phosphoserine.
MOD_RES 1208 1208 Phosphoserine. |
Keyword | Alternative splicing; Cell cycle; Cell membrane; Coiled coil; Complete proteome; Golgi apparatus; Membrane; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1210 AA |
Protein Sequence | MNDDNSDRTE DGSRYVFIRD KNSNPSEYYQ TSLSAQCPSV SHGDWNSDNP DAMVVDYEMD 60
PAVDSSESVS LSHQCVEELA YPEPSSDFMG KHEFTMYSEL TCQSPALVNT GKPQDLHSNC 120
DSLEAIQDEK FDPLKPCECR SDDDYACGDS PEVLELKQTY GMKVDTANYT FIARHDIEQG 180
QPLHAPGGLQ TTVRDRNALS SCGRTPPHSS KMYVRGVNYN RENFENLQAT PSKTLNTTFT 240
VISDVLMQTD SPDVGVQGQN SLGNVTKEYT DGTRRGLIGE KEIQAVTLVS DGMEVPNGSA 300
SQEFYCVSED DPNSETHSHG PYAQQEMGQN LRGTLPNCHV DGECPVLVPA FEKSKTRVLG 360
SECKVTVTED PHIDSHDNDS DIQSSTEELT LRSVSGQRGS PYEMGWGENG GAICTDKAGC 420
MSTPVEQPPN LSFRLEPAEV KKYNNVENGP RDAKRAPNLK GEPTNMPKPN LGKSATKTNT 480
TVGSKVRKTE IISYPTPNFK NIKAKVISRS VLQPKDTSIM KDTPSPQVTG GSSPSPGPSK 540
HLTMMNKAPR SDFKASKKAE IPINKTHKQQ FNKLITSQAA QVTTHSKNAS LGVPRTTSAT 600
KSNQENVDKT GSPHAGSETG SVAAFFQKIK GILPVKMKSS ECLEVTYVSH IDQISPEKGE 660
QDGEAPMEKQ ELGKQATNEI FESKSLLVGS APKTSTTPGR SSSKPDSRSL RKTPGLKAKV 720
GPTAACLRRK SESRTLGSDR ALSPQRIRRV SGSGGHAAIN KYEEKPPKQA FQNGSGPLYL 780
KPLVPRAHSH LLKTSPKGPS RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE 840
LAQYKTKCES QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH KTLSQELVSL 900
RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR TELENRLKDL YTAECEKLQS 960
IYIEEAEKYK TQLQEQFDNL NAAHETTKLE IEASHSEKVE LLKKTYETSL SEIKKSHEME 1020
KKSLEDLLNE KQESLEKQIN DLKSENDALN ERLKSEEQKQ LSREKANSKN PQVMYLEQEL 1080
ESLKAVLEIK NEKLHQQDMK LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR 1140
QLSTEQAALQ ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG 1200
SFSSPSISPR 1210 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |