| Tag | Content |
|---|
| CPLM ID | CPLM-014187 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipoyl synthase, mitochondrial |
Protein Synonyms/Alias | Lipoate synthase; LS; Lip-syn; Lipoic acid synthase |
Gene Name | Lias |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 317 | QPTKRHLKVEEYVTP | acetylation | [1] | | 365 | FLKNLVAKRKTKVSK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity). |
Sequence Annotation | METAL 105 105 Iron-sulfur 1 (4Fe-4S) (By similarity).
METAL 110 110 Iron-sulfur 1 (4Fe-4S) (By similarity).
METAL 116 116 Iron-sulfur 1 (4Fe-4S) (By similarity).
METAL 136 136 Iron-sulfur 2 (4Fe-4S-S-AdoMet) (By
METAL 140 140 Iron-sulfur 2 (4Fe-4S-S-AdoMet) (By
METAL 143 143 Iron-sulfur 2 (4Fe-4S-S-AdoMet) (By |
Keyword | 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome; S-adenosyl-L-methionine; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 373 AA |
Protein Sequence | MALRCWDAAR SLGSRIFGRY ACSVRALSSL PDEKKKFLHN GPDLQDFVSG DLADKSTWDD 60
YKGNLKRQKG ERLRLPPWLK TKIPMGKNYN KLKNTLRNLN LHTVCEEARC PNIGECWGGG 120
EYATATATIM LMGDTCTRGC RFCSVKTARN PPPLDPSEPD NTARAIAEWG LDYVVLTSVD 180
RDDVVDGGAE HIAKTVSCLK ERNPKILVEC LTPDFRGDLR AVEKVALSGL DVYAHNVETV 240
PELQRKVRDP RANFDQSLRV LKHAKEVQPD VVSKTSIMLG LGETDEQVYA TMKALRAADV 300
DCLTLGQYMQ PTKRHLKVEE YVTPEKFKYW EEVGNELGFH YTASGPLVRS SYKAGEFFLK 360
NLVAKRKTKV SKV 373 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:HAMAP. GO:0016992; F:lipoate synthase activity; IEA:HAMAP. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006954; P:inflammatory response; IEA:Compara. GO:0001843; P:neural tube closure; IEA:Compara. GO:0009249; P:protein lipoylation; IEA:HAMAP. GO:0032496; P:response to lipopolysaccharide; IEA:Compara. GO:0006979; P:response to oxidative stress; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |