CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017432
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MPN domain-containing protein 
Protein Synonyms/Alias
  
Gene Name
 MPND 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
140KLVNPAKKSGCGWASubiquitination[1]
228PEATTPGKRVDSKIRubiquitination[1]
443HTYLDKLKISLASRTubiquitination[1]
452SLASRTPKDQSLCHVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Probable protease (By similarity). 
Sequence Annotation
 DOMAIN 267 375 MPN.
 MOTIF 349 362 JAMM motif.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 8 8 Phosphoserine.
 MOD_RES 178 178 Phosphoserine.
 MOD_RES 181 181 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Hydrolase; Phosphoprotein; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MAAPEPLSPA GGAGEEAPEE DEDEAEAEDP ERPNAGAGGG RSGGGGSSVS GGGGGGGAGA 60
GGCGGPGGAL TRRAVTLRVL LKDALLEPGA GVLSIYYLGK KFLGDLQPDG RIMWQETGQT 120
FNSPSAWATH CKKLVNPAKK SGCGWASVKY KGQKLDKYKA TWLRLHQLHT PATAADESPA 180
SEGEEEELLM EEEEEDVLAG VSAEDKSRRP LGKSPSEPAH PEATTPGKRV DSKIRVPVRY 240
CMLGSRDLAR NPHTLVEVTS FAAINKFQPF NVAVSSNVLF LLDFHSHLTR SEVVGYLGGR 300
WDVNSQMLTV LRAFPCRSRL GDAETAAAIE EEIYQSLFLR GLSLVGWYHS HPHSPALPSL 360
QDIDAQMDYQ LRLQGSSNGF QPCLALLCSP YYSGNPGPES KISPFWVMPP PEMLLVEFYK 420
GSPDLVRLQE PWSQEHTYLD KLKISLASRT PKDQSLCHVL EQVCGVLKQG S 471 
Gene Ontology
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000555; JAB1_Mov34_MPN_PAD1. 
Pfam
 PF01398; JAB 
SMART
 SM00232; JAB_MPN 
PROSITE
  
PRINTS