| Tag | Content |
|---|
| CPLM ID | CPLM-019348 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 496 |
Protein Synonyms/Alias | Zinc finger protein with KRAB and SCAN domains 17 |
Gene Name | ZNF496 |
Gene Synonyms/Alias | ZKSCAN17 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 13 | CPRVLAPKESEEPRK | ubiquitination | [1] | | 325 | ELQDLQGKEVPQVSY | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | DNA-binding transcription factor that can both act as an activator and a repressor (By similarity). |
Sequence Annotation | DOMAIN 42 124 SCAN box.
DOMAIN 221 291 KRAB.
ZN_FING 406 428 C2H2-type 1; degenerate.
ZN_FING 435 457 C2H2-type 2.
ZN_FING 463 485 C2H2-type 3.
ZN_FING 522 545 C2H2-type 4.
ZN_FING 553 575 C2H2-type 5.
MOD_RES 185 185 Phosphoserine.
MOD_RES 299 299 Phosphoserine. |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 587 AA |
Protein Sequence | MPTALCPRVL APKESEEPRK MRSPPGENPS PQGELPSPES SRRLFRRFRY QEAAGPREAL 60
QRLWDLCGGW LRPERHTKEQ ILELLVLEQF LAILPREIQS WVRAQEPESG EQAVAAVEAL 120
EREPGRPWQW LKHCEDPVVI DDGDSPLDQE QEQLPVEPHS DLAKNQDAQP ITLAQCLGLP 180
SRPPSQLSGD PVLQDAFLLQ EENVRDTQQV TTLQLPPRIF QFNNHRSNGY ILEMLGSGGK 240
KAQIISVLSQ IYVSRVSPFK DMILCFSEED WSLLDPAQTG FYGEFIIGED YGVSMPPNDL 300
AAQPDLSQGE ENEPRVPELQ DLQGKEVPQV SYLDSPSLQP FQVEERRKRE ELQVPEFQAC 360
PQTVVPQNTY PAGGNPRSLE NSLDEEVTIE IVLSSSGDED SQHGPYCTEE LGSPTEKQRS 420
LPASHRSSTE AGGEVQTSKK SYVCPNCGKI FRWRVNFIRH LRSRREQEKP HECSVCGELF 480
SDSEDLDGHL ESHEAQKPYR CGACGKSFRL NSHLLSHRRI HLQPDRLQPV EKREQAASED 540
ADKGPKEPLE NGKAKLSFQC CECGKAFQRH DHLARHRSHF HLKDKARPFQ CRYCVKSFTQ 600
NYDLLRHERL HMKRRSKQAL NSY 623 |
Gene Ontology | GO:0016604; C:nuclear body; IEA:Compara. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0016032; P:viral reproduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |