UniProt Accession

 LRP1_YEAST; P38801; D3DL32 

Genbank Protein ID

 U10556; BK006934 

Genbank Nucleotide ID

 AAB68886.1; DAA06776.1 

Protein Name

 Exosome complex protein LRP1 

Protein Synonyms/Alias

 Like an rRNA processing protein 1; Yeast C1D domain-containing protein; rRNA processing protein 47 

Gene Name

 LRP1 

Gene Synonyms/Alias

 RRP47; YC1D; YHR081W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
141	NFQGKHTKFENDELA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. Required for activity of RRP6 in 7S pre-rRNA processing. Also has a role in 3'- processing of U4 and U5 small nuclear RNAs (snRNAs). Acts as a mRNA export factor. Mediates mRNA degradation upon UV irradiation. Maintains genome integrity where it is involved in both non- homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks. During NHEJ, required for joining 3'-overhanging ends. Also involved in telomere length regulation and maintenance. 

Sequence Annotation

  

Keyword

 Complete proteome; Exosome; Nucleus; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.
 GO:0003690; F:double-stranded DNA binding; IDA:SGD.
 GO:0003725; F:double-stranded RNA binding; IDA:SGD.
 GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IMP:SGD.
 GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:SGD.
 GO:0071033; P:nuclear retention of pre-mRNA at the site of transcription; IGI:SGD.
 GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IMP:SGD.
 GO:0000973; P:posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IMP:SGD.
 GO:0034475; P:U4 snRNA 3'-end processing; IMP:SGD.
 GO:0034476; P:U5 snRNA 3'-end processing; IMP:SGD. 

Interpro

 IPR011082; Exosome-assoc_fac/DNA_repair.
 IPR007146; Sas10/Utp3/C1D. 

Pfam

 PF04000; Sas10_Utp3 

SMART

  

PROSITE

  

PRINTS