UniProt Accession

 SCO2_HUMAN; O43819; Q3T1B5; Q9UK87 

Genbank Protein ID

 AF177385; AL021683; CR456569; BC102024; BC102025 

Genbank Nucleotide ID

 AAF05313.1; CAA16671.1; CAG30455.1; AAI02025.1; AAI02026.1 

Protein Name

 Protein SCO2 homolog, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 SCO2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
196	LGLTGSTKQVAQASH	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). 

Sequence Annotation

 DOMAIN 85 259 Thioredoxin.
 METAL 133 133 Copper.
 METAL 137 137 Copper.
 METAL 224 224 Copper.  

Keyword

 3D-structure; Cardiomyopathy; Chaperone; Complete proteome; Copper; Disease mutation; Metal-binding; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 266 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; TAS:UniProtKB.
 GO:0005507; F:copper ion binding; NAS:UniProtKB.
 GO:0006878; P:cellular copper ion homeostasis; IEA:InterPro.
 GO:0006825; P:copper ion transport; IEA:InterPro.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0003012; P:muscle system process; IEA:Compara.
 GO:0055114; P:oxidation-reduction process; TAS:UniProtKB.
 GO:0008535; P:respiratory chain complex IV assembly; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara. 

Interpro

 IPR003782; SCO1/SenC.
 IPR017276; Synth_of_cyt-c-oxidase_Sco1/2.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF02630; SCO1-SenC 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS