UniProt Accession

 DDX3Y_HUMAN; O15523; Q8IYV7 

Genbank Protein ID

 AF000985; AF000984; BC034942 

Genbank Nucleotide ID

 AAC51832.1; AAC51831.1; AAH34942.1 

Protein Name

 ATP-dependent RNA helicase DDX3Y 

Protein Synonyms/Alias

 DEAD box protein 3, Y-chromosomal 

Gene Name

 DDX3Y 

Gene Synonyms/Alias

 DBY 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
206	TRPTPVQKHAIPIIK	ubiquitination	[1]
250	DGPGEALKAVKENGR	ubiquitination	[2]
262	NGRYGRRKQYPISLV	ubiquitination	[1]
333	VDMMERGKIGLDFCK	ubiquitination	[1]
340	KIGLDFCKYLVLDEA	ubiquitination	[1]
371	EQDTMPPKGVRHTMM	ubiquitination	[1]
450	LVFVETKKGADSLED	ubiquitination	[1]
489	LHQFRSGKSPILVAT	ubiquitination	[1]
546	ATSFFNEKNMNITKD	ubiquitination	[1, 2]
552	EKNMNITKDLLDLLV	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable ATP-dependent RNA helicase. May play a role in spermatogenesis. 

Sequence Annotation

 DOMAIN 209 401 Helicase ATP-binding.
 DOMAIN 412 573 Helicase C-terminal.
 NP_BIND 198 205 ATP (By similarity).
 NP_BIND 222 229 ATP (By similarity).
 MOTIF 178 206 Q motif.
 MOTIF 345 348 DEAD box.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 69 69 Phosphotyrosine (By similarity).
 MOD_RES 74 74 Phosphoserine (By similarity).
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 103 103 Phosphotyrosine (By similarity).
 MOD_RES 123 123 Phosphoserine (By similarity).
 MOD_RES 129 129 Phosphoserine (By similarity).
 MOD_RES 281 281 Phosphotyrosine (By similarity).
 MOD_RES 341 341 Phosphotyrosine (By similarity).
 MOD_RES 464 464 Phosphotyrosine (By similarity).
 MOD_RES 588 588 Phosphoserine (By similarity).
 MOD_RES 592 592 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 660 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS