CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037675
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heat shock cognate 71 kDa protein 
Protein Synonyms/Alias
  
Gene Name
 HSPA8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
227NHFIAEFKRKHKKDIubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 627 AA 
Protein Sequence
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 60
MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS 120
SMVLTKMKEI AEAYLGKATK DAGTIAGLNV LRIINEPTAA AIAYGLDKKV GAERNVLIFD 180
LGGGTFDVSI LTIEDGIFEV KSTAGDTHLG GEDFDNRMVN HFIAEFKRKH KKDISENKRA 240
VRRLRTACER AKRTLSSSTQ ASIEIDSLYE GIDFYTSITR ARFEELNADL FRGTLDPVEK 300
ALRDAKLDKS QIHDIVLVGG STRIPKIQKL LQDFFNGKEL NKSINPDEAV AYGAAVQAAI 360
LSGDKSENVQ DLLLLDVTPL SLGIETAGGV MTVLIKRNTT IPTKQTQTFT TYSDNQPGVL 420
IQVYEGERAM TKDNNLLGKF ELTGIPPAPR GVPQIEVTFD IDANGILNVS AVDKSTGKEN 480
KITITNDKGR LSKEDIERMV QEAEKYKAED EKQRDKVSSK NSLESYAFNM KATVEDEKLQ 540
GKINDEDKQK ILDKCNEIIN WLDKNQTAEK EEFEHQQKEL EKVCNPIITK LYQSAGGMPG 600
GMPGGFPGGG APPSGGASSG PTIEEVD 627 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.