CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 7 
Protein Synonyms/Alias
  
Gene Name
 Fbxo7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
280NVKSVQLKPGAYVRRacetylation[1]
299ESAAKVYKDLKKLSRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 (By similarity). 
Sequence Annotation
 DOMAIN 329 375 F-box.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 522 AA 
Protein Sequence
MKLRVRLQKR TQPLEVPESE PTLGQLRAHL IQDLLPTLGF SSDTRFAITL NNKDALTGDE 60
ETLASYGIVS GDLICLVLED EMPAPNLPSS TDSEHSSLQN NDQPPLAATS SQANIPDEQG 120
SDSSHGQVTQ YDAWTDDSME GPSHSAEAVS IQDAMSVEEA SGFHPLEPML CSETEDGQVP 180
HSLEALYQSA GCSTVSDALI VLVHLLMLES GYIPQGTEAK AASMPEKWKS SGVYKLQYTH 240
PLCEGGSAVL TCVPLGKLIM INATIKVNGG IKNVKSVQLK PGAYVRRAEP GESAAKVYKD 300
LKKLSRLFKD QLVYPLLAFT RQVLNLPDVF GLVVLPLELK LRIFRLLDVH SVLALSAVCH 360
DLLIASNDPL LWRCLYLRDF RDSTIRGPDT DWKELYRKKH IQRKEAQRMR HVMYLPSVHP 420
IPFCPIPVYP RPYLPTTLLP PGIIGGEYDE RPILPSVGDP VTSLIPRPGE PPSQFRPVRP 480
RFDPVGPLPG SNSLLPGRAS PNNRFPFRPG RGRSADNRLP YL 522 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0031647; P:regulation of protein stability; IEA:Compara. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR021625; Inhibitor_PI31. 
Pfam
 PF11566; PI31_Prot_N 
SMART
  
PROSITE
 PS50181; FBOX 
PRINTS