CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024324
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein KIAA1109 
Protein Synonyms/Alias
 Fragile site-associated protein homolog 
Gene Name
 Kiaa1109 
Gene Synonyms/Alias
 Fsa; Kiaa1371 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
3194LSNRLQTKASPGSSSubiquitination[1]
4641TQQFDTSKRALSTWGubiquitination[1]
4841TENSTTVKNSSLLSGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 MOD_RES 1301 1301 Phosphoserine (By similarity).
 MOD_RES 1305 1305 Phosphoserine (By similarity).
 MOD_RES 2931 2931 Phosphoserine.
 MOD_RES 3653 3653 Phosphoserine.
 MOD_RES 4613 4613 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5005 AA 
Protein Sequence
MDQRKNDSIV PSITQLEDFL TEHNSNVVWL LVATILSCGW IIYLTYYNSR NVGLILTLVL 60
NRLYKHGYIH IGSFSFSVLS GKVMVREIYY ITEDMSIRIQ DGFIIFRWWK MYNPKQKQHD 120
PKAETRLYIT VNDFEFHVYN RSDLYGRLQE LFGLEPTIIP PKKDDDKTRE NGRTRTQSKI 180
ERVKVKTESQ DPTSSWRSLI PVIKVNVSTG RLAFGNHYQP QTLCINFDDA FLTYTTKPPS 240
SHLDQFMHIV KGKLENVRVM LVPSPRYVGL QNDEPPRLMG EGFVVLQSND VDLYYYMDEP 300
GLVPEETEES TEGDISSEDC KLQDLPPCWG LDIVCGKGTD FNYGPWADRQ RDCLWKFFFP 360
PDYQVLKVSE IAQPGRPRQI LAFELRMNII TDATIDLLFT KNRETNAVHV NVGAGSYLEI 420
NIPMTVDENG YTPAIKGQLL HVDATTSMQY RTLLEAEMLA FHINASYPRI WNMPQTWQCE 480
LEVYKATYHF IFAQKNFFTD LIQDWSSDNA PDIFSFVPYT WNFKIMFHQF EMIWAANQHN 540
WIDCSTKQQE NVYLAACGET LNIDFSLPFT DFVPATCNTR FSLRGEDVDL HLFLPDCHPS 600
KYSLFMLVKN CHPNKMVPET GIPAECQSGQ KTVKPKWRNV TQEKAGWVEC WTVPSVMLTI 660
DYTWHPIYPQ KADEQLKQSL SEMEETMLSV LRPAQKTSER VVSSPSMSPR PPVDPSELPP 720
DKLHVEMELS PDSQITLYGP LLNAFLCIKE NYFGEDDMYM DFEEVISSPV LSLSTSSSSG 780
WTAVGMDNDK RENESSAKSI HPLALRPWDI TVLVNLYKVH GRLPVHGTTD GPECPTAFLE 840
RLCFEMKKGF RETMLQLVLS PLNVFVSDNY QQRPPVDEVL REGHINLSGL QLRAHAMFSA 900
EGLPLGSDSL EYAWLIDVQA GSLTAKVTAP QLACLLEWGQ TFVFHVVCRE YELERPKSVI 960
VCQHGIDRRF CESKLSCIPG PCPTSDDLKY TMTRLAIDGS DIYIVEHGCA TNIKMGAVRI 1020
ANCNLHNQSV GEGISAAIQD FQVRQYIEQL NNCRIGLQPA VLRRAYWLEA GSANLGLITV 1080
DIALAADHHS KHEAQRHFLE THDARTKRLW FLWPDDTLKN KRCRNKCGCL GGCRFFGGTV 1140
TGLDFFKLEE LTPSSSSAFS STSAESDMYY GQSLLQPGEW IITKEIPKTV DGNVNSMKRK 1200
EWENKSVGIE GERKTQHLSL QVPLRSHSSS SSSEENSSSS AAQPLLAGEK ESPSSAADDH 1260
SVQKDLLHSA RRDDGQASVP TEISGTSPVS PNTQDKSVGQ SPLRSPLKRQ ASVCSTRLGS 1320
TKSLTAAFYG DKQPVTVGVQ FSSDVSRSDE NVLDSPKQRR SFGSFPYTPS ADSNSFHQYR 1380
SMDSSMSMAD SEAYFSAAEE FEPISSDEGP GTYPGRKKKK KQMQQIDYSR GSIYHSVEGP 1440
LAVHGEGITD PRTLPFKTHP SQASFVSALG GEDEVIEHVY IVEGEKRGES EQVTSQQPVM 1500
SCYHTYLTQF QVINWSVKHP TNKRTSKSSL HRPLDLDTPT SEESSSSFEQ LCVPTFKVIK 1560
QGLTANSLLD RGMQLSGSTS NTPYTPLDKK IVDTTDDETL TEEWTLDQPV AQTKTTAIVE 1620
VKGTVDVVLT PLVAEALDRY IEAMVHRVST RHPAAIVDDL HTKVLREAVQ NSKTTFSENL 1680
SPKQDIRGTK TEHPMIGTTN QGQIQTNVTT KQDNVTIKGL QANVSIPKVN LCLLQASVEE 1740
SPATVPSRSV THVSLVALCF DRIATQVRMN RGVVEETANN VDAGKTSNFD RYVHASKMQP 1800
QSSGSLRSNA GAEKGKEIAA KLNIHRVHGQ LRGLDTTDIG TCAITAIPFE KSKVLFTLEE 1860
LDEFTFVDET DQQAIPDVTR IGPSQEKWGW IMFECGLENL TIKGGRQSGA VLYNSFGIMG 1920
KNSVTERGGV LTSNNSSDSP TGSGYNTDVS DDNLPCDRTS PSSDINGNSV SDEQDEGVES 1980
DDLKKDLPLM PPPPDSCSMK LTIKEIWFSF AAPTNVRSPA HAFSRQLNLL STATPAVGAW 2040
LVPIDQLKSS LNKLETEGTL RICAVMGCIM TEALENKSVH FPLRSKYNRL TKVARFLQEN 2100
PSCLLCNILH HYLHQANYSI IDDATMSDGL PALVTLKKGL VALARQWMKF IVVTPAFKGV 2160
SLHRPAQPLK PPATVDQEHE EGLGLDNGGG LQSDTSADGA EFEFDAATVS EHTMLLEGTA 2220
NRPPPGSSGP VTGAEIMRKL SKTHTHSDSA LKIKGIHPYH SLSYTSGDTA TDSPVHVGRA 2280
GMPVKESPRK ESLLSYLTGS FPSLHNLLEG TPQRSSAAVK SSSLTRTGNT VATDMLSEHP 2340
LLSEPSSVSF YNWMSNAVGN RGSVVQESPV TKSGHNSLPT GVAPNLPTIP SASDFNTVLS 2400
SDQNTLDGTH SQHSTSQDDV AGVEEANQGF PAVQLADAQV VFKPLLSHTG IQSQDTMPLC 2460
YRMYFGEHLS FSGTLDCLRA DIVDSDTAKD RKGKRARRQG HVNLPPLEFK PALMLETFSI 2520
SAVVMEKSVC TPQNSTSALS FHDLNKRYYN TFHCNFTISC QSISQHVDMA LVRLIHQFST 2580
MIDDIKATQT DIKLSRYTAG SASPTPTFKT RKHRDFRSSD FSRSSRGSLN GGNRVNNAKN 2640
KRANNENNKK ESRNKNSLGR SERRTSKVSR KGSKDVVDHM TIHMDDSDSI TVSEQSEPSA 2700
ECWQNMYKLL NFYSLISDPT GILEKSSETF GPAGVRSPTE PTCRVVFENE QDNNSLTKTQ 2760
RKRSLVTSEP QHVTLIVFGI GMVNRTHLEA DIGGLTMESE LKRIHGSFTL KEKMKDVLHQ 2820
KMTETCATAH IGGVNIVLLE GITPNIQLED FPTSPTSTAK QEFLTVVKCS IAKSQALYSA 2880
QRGLKTNNAA VFKVGAISIN IPQHPATLHS MMVRSSHQLS KQISDLIRQP STAPQPMKED 2940
IATPLPSEKT PTSVNQTPIE TNEFPQLPEG LEKKPIVLKF SAMLDGIAIG AALLPSLKAE 3000
YKMGRMRSHG MTGAQTRFTF ELPNHRLRFT SKVSATDMST IPPSASLNLP PVTMSGKYIM 3060
EEHDSYSDQV WSIDELPSKQ GYYLQGNYLR CVAEVGSFEH NLTTDLLNHL VFVQKVFMKE 3120
VNEVIQKVSG GEQPIPLWNE HDGTTDGDKP KILLYSLNLQ FKGIQVTATT PSMRAVRFET 3180
GLIELELSNR LQTKASPGSS SYLKLFGKCQ VDLNLALGQI VKHQVYEEAG SDFHQVAYFK 3240
TRIGLRNALR EEISGSSDRE AVLITLNRPI VYAQPVAFDR AVLFWLNYKA AYDNWNEQRM 3300
ALHKDIHMAT KEVVDMLPGI QQTSAQAFGT LFLQLTVNDL GICLPITNTA QSNHTGDLDT 3360
GSALVLTIES TLITACSSES LVSKGHFKNF CIRFADGFET SWDDWKPEIR GDLVMNACVV 3420
PDGTYEVCSR TTGQAAAESS SAGTWTLNVL WKMCGIDVHM DPNIGKRLNA LGNTLTTLTG 3480
EEDIDDIADL NSVNIADLSD EDEVDTMSPT IHTSSDGSSV SGDGHKLTFG QRLVNHLLGL 3540
APPNQRYSVP AEYLCDSEMR GSPQSSQSHL KACRAHSWGN EAVDYRRQGT SSSQPGELRG 3600
RKIMKRLVDI RELNEQAKVI DDLKKLGASE GTINQEIQRY QQLESVAVND IRRDVRKKLR 3660
RSSMRAASLK DKWGLGYKPS YSRSKSISAS GRPPLKRMER ASSRIGETDE LPEIRVDAAS 3720
PGPRVTFNIQ DTLKNTVWGS SPQSRSPGEG YFQFPEETEL DLLSVTIEGP SHYSSNSEGS 3780
CSVFSSPKTT GGFSPSVPFQ SEDGRRDDSL SSTSEDSEKD EKDEDRERER FYIYRKPSHT 3840
SRKKATGFAA VHQLLTERWP TTPVNRSLSG TATERNIDFE LDIRVEIDSG KCVLHPTTLL 3900
QEHDDISLRR SYDRSSRSLD QDSPSKKKKF QTNYASTTHL MTGKKVPSSL QTKPSDLETT 3960
VFYIPGVDVK LHYNSKTLKT ESPNASRGSS LPRTLSKESK LYAKGKGSGG VKTAKLYAWV 4020
ALQSLPEEMV ISPCLLDFLE KALETIPITP IERNYTAVSS QDEDMGHFDI PDPMEESTTS 4080
LVSSSTSAYS SFPVDVVVYV RVQPSQIKFS CLPVSRVECM LKLPSLDLVF SSNRGELETL 4140
GTTYPAETVS PGSNAPQTGA KTSASKAGMP GSSGLGSPLG RSRHSSSQSD LTGSSSSSSG 4200
LSFTACMSDF SLYVFHPYGA GKQKSTVSGL TSGSGGLGNV DEEPTSVTGR KDSLSINLEF 4260
VKVSLSRIRR SGGASFFESQ SVSKSTSKMD TTLINISAVC DIGSASFKYD MRRLSEILAF 4320
PRAWYRRSIA RRLFLGDQTV NLPTSGPGTP DSIEGVSQHL SPESSRKAYC RTWDQPSQSA 4380
SFTHMPQSPN VFNEHMTNNT MSPGTAAQSL KSPASIRSRS VSDSSVPRRD SISKTSTPVN 4440
KSNKAASQQG TPWETLVVFA INLKQLNVQM NMSNVMGNTT WTTSGLKSQG RLSVGSNRDR 4500
EISMSVGLGR SQLDSKGGVV GGTIDVNALE MVAHISEHPN QQPNHKIQIT MGSTESRVDY 4560
MGSSILMGIF SNADLKLQDE WKVNLYNALD SSMTDKSEIF VHGDLKWDIF QVMISRSTTP 4620
DLIKIGMKLQ EFFTQQFDTS KRALSTWGPV PYLPPKTMTN NLEKNSQEQL LDAAHHRHWP 4680
GVLKVVSGCH ISLFQVPLPE DGMQFGGSMS LHGNHMTLAC FHGPNFRSKS WALFHLEEPN 4740
IAFWTEAQKI WEDGSSDHST YIVQTLDFHL GHNTMVTKPC GALESPMATI TKITRRRHEN 4800
PPHGVASVKE WFNYVTATRN EELNLLRNVD ANNTENSTTV KNSSLLSGFR GGSSYNHETE 4860
TIFALPRMQL EFKSIHVQEP QEPSLQDASL KPKVECSVVT EFTDHICVTM DAELIMFLHD 4920
LVSAYLKEKE KAIFPPRILS TRPGQKCPLI IHDDSSSDRD REDSITYTTV DWRDFMCNTW 4980
HLEPTLRLIS WTGRKIDPVG VDYILQKLGF HHARTTIPKW LQRGVMDPLD KVLSVLIKKL 5040
GTALQDEKEK KGKDKEEH 5058 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; NAS:BHF-UCL.
 GO:0060612; P:adipose tissue development; NAS:BHF-UCL.
 GO:0045444; P:fat cell differentiation; NAS:BHF-UCL.
 GO:0006629; P:lipid metabolic process; NAS:BHF-UCL.
 GO:0019915; P:lipid storage; NAS:BHF-UCL.
 GO:0051647; P:nucleus localization; NAS:BHF-UCL.
 GO:0001558; P:regulation of cell growth; NAS:BHF-UCL.
 GO:0007283; P:spermatogenesis; NAS:BHF-UCL. 
Interpro
 IPR018863; Fragile_site-assoc_C. 
Pfam
 PF10479; FSA_C 
SMART
  
PROSITE
  
PRINTS