| Tag | Content |
|---|
| CPLM ID | CPLM-018875 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitogen-activated protein kinase kinase kinase kinase 1 |
Protein Synonyms/Alias | Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1 |
Gene Name | MAP4K1 |
Gene Synonyms/Alias | HPK1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 33 | GTYGEVFKARDKVSG | ubiquitination | [1] | | 37 | EVFKARDKVSGDLVA | ubiquitination | [1] | | 600 | RKNMVSTKIQDTKGC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. |
Sequence Annotation | DOMAIN 17 274 Protein kinase.
DOMAIN 495 800 CNH.
NP_BIND 23 31 ATP (By similarity).
ACT_SITE 137 137 Proton acceptor (By similarity).
BINDING 46 46 ATP (By similarity).
MOD_RES 405 405 Phosphoserine.
MOD_RES 407 407 Phosphoserine.
MOD_RES 413 413 Phosphoserine.
MOD_RES 421 421 Phosphoserine.
MOD_RES 586 586 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 833 AA |
Protein Sequence | MDVVDPDIFN RDPRDHYDLL QRLGGGTYGE VFKARDKVSG DLVALKMVKM EPDDDVSTLQ 60
KEILILKTCR HANIVAYHGS YLWLQKLWIC MEFCGAGSLQ DIYQVTGSLS ELQISYVCRE 120
VLQGLAYLHS QKKIHRDIKG ANILINDAGE VRLADFGISA QIGATLARRL SFIGTPYWMA 180
PEVAAVALKG GYNELCDIWS LGITAIELAE LQPPLFDVHP LRVLFLMTKS GYQPPRLKEK 240
GKWSAAFHNF IKVTLTKSPK KRPSATKMLS HQLVSQPGLN RGLILDLLDK LKNPGKGPSI 300
GDIEDEEPEL PPAIPRRIRS THRSSSLGIP DADCCRRHME FRKLRGMETR PPANTARLQP 360
PRDLRSSSPR KQLSESSDDD YDDVDIPTPA EDTPPPLPPK PKFRSPSDEG PGSMGDDGQL 420
SPGVLVRCAS GPPPNSPRPG PPPSTSSPHL TAHSEPSLWN PPSRELDKPP LLPPKKEKMK 480
RKGCALLVKL FNGCPLRIHS TAAWTHPSTK DQHLLLGAEE GIFILNRNDQ EATLEMLFPS 540
RTTWVYSINN VLMSLSGKTP HLYSHSILGL LERKETRAGN PIAHISPHRL LARKNMVSTK 600
IQDTKGCRAC CVAEGASSGG PFLCGALETS VVLLQWYQPM NKFLLVRQVL FPLPTPLSVF 660
ALLTGPGSEL PAVCIGVSPG RPGKSVLFHT VRFGALSCWL GEMSTEHRGP VQVTQVEEDM 720
VMVLMDGSVK LVTPEGSPVR GLRTPEIPMT EAVEAVAMVG GQLQAFWKHG VQVWALGSDQ 780
LLQELRDPTL TFRLLGSPRL ECSGTISPHC NLLLPGSSNS PASASRVAGI TGL 833 |
Gene Ontology | GO:0005524; F:ATP binding; IDA:UniProtKB. GO:0008349; F:MAP kinase kinase kinase kinase activity; IDA:UniProtKB. GO:0005083; F:small GTPase regulator activity; IEA:InterPro. GO:0007257; P:activation of JUN kinase activity; TAS:ProtInc. GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |