CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015069
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 A-kinase anchor protein SPHKAP 
Protein Synonyms/Alias
 SPHK1-interactor and AKAP domain-containing protein 
Gene Name
 Sphkap 
Gene Synonyms/Alias
 Kiaa1678 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1332EALMRKNKIIADDSEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity). 
Sequence Annotation
 REGION 914 931 PKA-RII subunit binding domain (By  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1687 AA 
Protein Sequence
MSTPGFLCKA MWVVEPNSAT CLSAALPVKR HCQESSNVES PLMHEGPEPQ QITSSAAGNL 60
AGSITACKKV LRSNSLLEST DYWLQNQRTP CQIGFVEDES ENCASVCFVN LDVNKDACIT 120
ENLQQKLVNV SPDLPNLISS MNVQQPKENE IVLLSGLASG NPQADFDVSQ CPWLPDICLV 180
QCARGNRPNS TNCIIFEINK FLIGLEVVQE RQLHLETNVL KLEDDTNCSL SSIEEDFLTA 240
SEHLEEEIEV DDCRSGLENT NVSANVLESK KPKETTQEGW DYHKEKLHCA LGEKHIRKHR 300
TPSTKTEGSK ENTEENTSLK SLNRLVRPSH LKSEVAGNKQ LATNYSYPEN IKGELETSQM 360
LFIPRDAYLS MVKKDVLSPC SVLSEQGGSH RDHDVTPNPL PPVQNGEAST GEYATNLAES 420
VMQDAFIRLS QSQPTLPQES AVSFSMRSAL LPSGCCTKDM VVPRSWNELP KIVIVQSPDG 480
SDTVPEPNVS SWPDMEFVET SGIFSADSSS RPTQSALEVA LACAATVIGT ISSPQATERF 540
AMEQESLVST YAQRGTGVQQ TQVPQAFMAP STTEYSFPSA LCGMTQVASA VAVCGLCEKE 600
EATCPVAPTD LLPTSGASEE ISSIGSLVME RSTELGKEAI AEALLREATL ILARPDAYSS 660
LGELLESVNQ RIIETTSKTQ TLCTESVQRN ELAHTLSNVI LKHSVDELHQ KTTMAHPTDE 720
RHPCGTLDTL MESVNQLLHN VICFTFKKMN HIVTLSEHPS FDQAAGQAWV KAFACPSSQP 780
LSNAHGTGLV IRNLVEDASP KSNKGGARPE LVNNPRLQSE FSCSHRMFDS TAKSFPKEIY 840
LKGIMGEDTR NPHHTLNYDS NERRASTDLG KLTTASEGCS GFQETEDSIV PNTQEKYICA 900
TPLNNEAQVN LSLLGDDLSV PAQSTLEAKQ SEVYGITDFA EELAETVVSM ATEIAAICLD 960
NSNGKQPWFC AWKRGNEFLT APNGSCRSLK RKKENSSAGS TVRKHKPPRL SEIKRKADEH 1020
PELKEKLMNR VMDESMNLED IPDSVSTFAN EVAAKIMNLT EFSMVDGVWQ GQSCSRTRLL 1080
GGDRWNRLKA SSCESIPEED SEARVFVNSL GLMSTLSQPV SRASSVSKQS SCESITDEFS 1140
RFMVKQMENE GRGFELLLDY YAGKNASSIM SSAMQQACQK NDHLNVRPSC PSKQSSTESI 1200
TEEFYRYMLR DIAKESKDGA SSRRSSHDWT TGLLSPSTRS PLCYRQSSMP DSRSPCSRLT 1260
VNAPVKANSL DGFAQNCPQD SVNVQPVSRA SSSGLCKSDS CLYRRSGTDQ ITNMLIHETW 1320
ASSIEALMRK NKIIADDSEA ANASPGPVSS GSPLQVEKNA NRLATSKGHR GPTLLVQESV 1380
DYQRKDAVTE GNHSPVSSPG KTAPVKKPSD FDPRRETSAC HNAAGLNSPR RSLCSRDVPL 1440
IQIETDQKEE CIGEPGPFLS QSGSLEETEG HQPEETIPDV ARNEDTAPST CQSSRDSLET 1500
SGEVEVEVLK EDIPRDESRN PPSSSEESTG SWSQLANEED IPDDTSSFLQ LSERSMSNGN 1560
SSGTSSLGIM DLDIYQESIP SSPMINELVE EKEILKEQSE SIKEHASGLP GRAASPQRSL 1620
LVINFDLEPE CPDAELRATL QWIAASELGI PTIYFKKSQE SRIEKFLDVV KLVQQKSWKV 1680
GDIFHAVVQY CKLHAEQKER TPSLFDWLLE LG 1712 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI. 
Interpro
 IPR018292; AKAP_110_C.
 IPR008382; SPHK1-interactor_AKAP_110. 
Pfam
 PF05716; AKAP_110 
SMART
  
PROSITE
  
PRINTS