CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037266
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription factor HES-4 
Protein Synonyms/Alias
  
Gene Name
 HES4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65VPDPQSSKPVMEKRRubiquitination[1]
70SSKPVMEKRRRARINubiquitination[1]
103SRHSKLEKADILEMTubiquitination[1]
135ADPAVLGKYRAGFHEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 247 AA 
Protein Sequence
MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKVGSR PGVRGATGGR EGRGTQPVPD 60
PQSSKPVMEK RRRARINESL AQLKTLILDA LRKESSRHSK LEKADILEMT VRHLRSLRRV 120
QVTAALSADP AVLGKYRAGF HECLAEVNRF LAGCEGVPAD VRSRLLGHLA ACLRQLGPSR 180
RPASLSPAAP AEAPAPEVYA GRPLLPSLGG PFPLLAPPLL PGLTRALPAA PRAGPQGPGG 240
PWRPWLR 247 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011598; bHLH_dom.
 IPR003650; Orange.
 IPR018352; Orange_subgr. 
Pfam
 PF07527; Hairy_orange
 PF00010; HLH 
SMART
 SM00353; HLH
 SM00511; ORANGE 
PROSITE
 PS50888; BHLH
 PS51054; ORANGE 
PRINTS