CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NACHT, LRR and PYD domains-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 NLRP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
297RSQDPLVKRSWPDYVubiquitination[1]
340QGAAGIGKSTLARQVubiquitination[1]
855GLTAEDCKDLAFGLRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1375 AA 
Protein Sequence
MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPAQPEKTSG MEVASYLVAQ 60
YGEQRAWDLA LHTWEQMGLR SLCAQAQEGA GHSPSFPYSP SEPHLGSPSQ PTSTAVLMPW 120
IHELPAGCTQ GSERRVLRQL PDTSGRRWRE ISASLLYQAL PSSPDHESPS QESPNAPTST 180
AVLGSWGSPP QPSLAPREQE APGTQWPLDE TSGIYYTEIR EREREKSEKG RPPWAAVVGT 240
PPQAHTSLQP HHHPWEPSVR ESLCSTWPWK NEDFNQKFTQ LLLLQRPHPR SQDPLVKRSW 300
PDYVEENRGH LIEIRDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVKEA WGRGQLYGDR 360
FQHVFYFSCR ELAQSKVVSL AELIGKDGTA TPAPIRQILS RPERLLFILD GVDEPGWVLQ 420
EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG 480
FSESSRKEYF YRYFTDERQA IRAFRLVKSN KELWALCLVP WVSWLACTCL MQQMKRKEKL 540
TLTSKTTTTL CLHYLAQALQ AQPLGPQLRD LCSLAAEGIW QKKTLFSPDD LRKHGLDGAI 600
ISTFLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYVLEDE KGRGKHSNCI IDLEKTLEAY 660
GIHGLFGAST TRFLLGLLSD EGEREMENIF HCRLSQGRNL MQWVPSLQLL LQPHSLESLH 720
CLYETRNKTF LTQVMAHFEE MGMCVETDME LLVCTFCIKF SRHVKKLQLI EGRQHRSTWS 780
PTMVVLFRWV PVTDAYWQIL FSVLKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE 840
TLRLAGCGLT AEDCKDLAFG LRANQTLTEL DLSFNVLTDA GAKHLCQRLR QPSCKLQRLQ 900
LVSCGLTSDC CQDLASVLSA SPSLKELDLQ QNNLDDVGVR LLCEGLRHPA CKLIRLGLDQ 960
TTLSDEMRQE LRALEQEKPQ LLIFSRRKPS VMTPTEGLDT GEMSNSTSSL KRQRLGSERA 1020
ASHVAQANLK LLDVSKIFPI AEIAGKSHEE SSPEVVPVEL LCVPSPASQG DLHTKPLGTD 1080
DDFWGPTGPV ATEVVDKEKN LYRVHFPVAG SYRWPNTGLC FVMREAVTVE IEFCVWDQFL 1140
GEINPQHSWM VAGPLLDIKA EPGAVEAVHL PHFVALQGGH VDTSLFQMAH FKEEGMLLEK 1200
PARVELHHIV LENPSFSPLG VLLKMIHNAL RFIPVTSVVL LYHRVHPEEV TFHLYLIPSD 1260
CSIRKAIDDL EMKFQFVRIH KPPPLTPLYM GCRYTVSGSG SGMLEILPKE LELCYRSPGE 1320
DQLFSEFYVG HLGSGIRLQV KDKKDETLVW EALVKPGRNT SQPWNLRCNR DARRY 1375 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006952; P:defense response; IEA:InterPro. 
Interpro
 IPR004020; DAPIN.
 IPR011029; DEATH-like_dom.
 IPR000767; Disease_R.
 IPR025307; FIIND_dom.
 IPR001611; Leu-rich_rpt.
 IPR007111; NACHT_NTPase.
 IPR027417; P-loop_NTPase. 
Pfam
 PF13553; FIIND
 PF02758; PYRIN 
SMART
  
PROSITE
 PS50824; DAPIN
 PS51450; LRR
 PS50837; NACHT 
PRINTS
 PR00364; DISEASERSIST.