| Tag | Content |
|---|
| CPLM ID | CPLM-023732 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acyl-coenzyme A thioesterase 9, mitochondrial |
Protein Synonyms/Alias | Acyl-CoA thioesterase 9; Acyl-CoA thioester hydrolase 9 |
Gene Name | ACOT9 |
Gene Synonyms/Alias | CGI-16 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 178 | VARDSENKGPAFVNP | ubiquitination | [1] | | 217 | FSSTSLLKMAPSAEE | ubiquitination | [1] | | 374 | EVPLVFPKTYGESML | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. |
Sequence Annotation | MOD_RES 103 103 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Hydrolase; Mitochondrion; Polymorphism; Reference proteome; Serine esterase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 439 AA |
Protein Sequence | MRRAPCVRDK LREIVGASTN WRDHVKAMEE RKLLHSFLAK SQDGLPPRRM KDSYIEVLLP 60
LGSEPELREK YLTVQNTVRF GRILEDLDSL GVLICYMHNK IHSAKMSPLS IVTALVDKID 120
MCKKSLSPEQ DIKFSGHVSW VGKTSMEVKM QMFQLHGDEF CPVLDATFVM VARDSENKGP 180
AFVNPLIPES PEEEELFRQG ELNKGRRIAF SSTSLLKMAP SAEERTTIHE MFLSTLDPKT 240
ISFRSRVLPS NAVWMENSKL KSLEICHPQE RNIFNRIFGG FLMRKAYELA WATACSFGGS 300
RPFVVAVDDI MFQKPVEVGS LLFLSSQVCF TQNNYIQVRV HSEVASLQEK QHTTTNVFHF 360
TFMSEKEVPL VFPKTYGESM LYLDGQRHFN SMSGPATLRK DYLVEP 406 |
Gene Ontology | GO:0005739; C:mitochondrion; ISS:HGNC. GO:0003986; F:acetyl-CoA hydrolase activity; ISS:HGNC. GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. GO:0006637; P:acyl-CoA metabolic process; ISS:HGNC. |
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Pfam | |
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PROSITE | |
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