CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase RNF123 
Protein Synonyms/Alias
  
Gene Name
 RNF123 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34YDGNRVRKWNVTTTNubiquitination[1]
321HCSSREGKESTEMKEubiquitination[2, 3]
327GKESTEMKEETAEERubiquitination[2, 3]
369LKLLLDNKDDNGGEAubiquitination[2, 3]
384SRYIFLTKFRKFLQEubiquitination[4]
387IFLTKFRKFLQENASubiquitination[2, 3]
468GLLSHLRKTLKDDLAubiquitination[1]
471SHLRKTLKDDLASKAubiquitination[1, 2, 3]
652RRCPKRRKDILAELTubiquitination[1]
660DILAELTKSQKVFSEubiquitination[1, 3, 4]
663AELTKSQKVFSEKLDubiquitination[1]
668SQKVFSEKLDHLSRRubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 762 AA 
Protein Sequence
MQIGWCTISC RFNQEEGVGD THNSYAYDGN RVRKWNVTTT NYGKAWAAGD IVSCLIDLDD 60
GTLSFCLNGV SLGTAFENLS RGLGMAYFPA ISLSFKESVA FNFGSRPLRY PVAGYRPLQD 120
PPSADLVRAQ RLLGCFRAVL SVELDPVEGR LLDKESSKWR LRGQPTVLLT LAHIFHHFAP 180
LLRKVYLVEA VLMSFLLGIV EKGTPTQAQS VVHQVLDLLW LFMEDYEVQD CLKQLMMSLL 240
RLYRFSPIVP DLGLQIHYLR LTIAILRHEK SRKFLLSNVL FDVLRSVVFF YIKSPLRVEE 300
AGLQELIPTT WWPHCSSREG KESTEMKEET AEERLRRRAY ERGCQRLRKR IEVVEELQVQ 360
ILKLLLDNKD DNGGEASRYI FLTKFRKFLQ ENASGRGNMP MLCPPEYMVC FLHRLISALR 420
YYWDEYKASN PHASFSEEAY IPPQVFYNGK VDYFDLQRLG GLLSHLRKTL KDDLASKANI 480
VIDPLELQST AMDDLDEDEE PAPAMAQRPM QALAVGGPLP LPRPGWLSSP TLGRANRFLS 540
TAAVSLMTPR RPLSTSEKVK VRTLSVEQRT REDIEGSHWN EGLLLGRPPE EPEQPLTENS 600
LLEVLDGAVM MYNLSVHQQL GKMVGVSDDV NEYAMALRDT EDKLRRCPKR RKDILAELTK 660
SQKVFSEKLD HLSRRLAWVH ATVYSQEKML DIYWLLRVCL RTIEHGDRTG SLFAFMPEFY 720
LSVAINSYSA LKNYFGPVHS MEELPGDGTI QAEAEAEKGS LV 762 
Gene Ontology
  
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
  
PROSITE
 PS50188; B302_SPRY 
PRINTS