CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009120
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Epiplakin 
Protein Synonyms/Alias
 450 kDa epidermal antigen 
Gene Name
 EPPK1 
Gene Synonyms/Alias
 EPIPL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
97GQLLPVSKALQQGLVubiquitination[1, 2, 3]
574VTPGELLKAEIIDQDubiquitination[2, 4]
680IGPDVFAKLLSAERAubiquitination[1, 2, 3, 4]
1564VAEMDSVKRSLEGGNubiquitination[2]
1669SLFQAMQKDLIVREHubiquitination[2]
2384ADPSDDTKGFFDPNTubiquitination[2]
2739RDLAQGTKTLQEVTEubiquitination[2]
2751VTEMDSVKRYLEGTSubiquitination[2]
2833VGGEIQEKLLSAERAubiquitination[2, 4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
  
Sequence Annotation
 REPEAT 34 71 Plectin 1.
 REPEAT 72 109 Plectin 2.
 REPEAT 110 147 Plectin 3.
 REPEAT 148 185 Plectin 4.
 REPEAT 192 225 Plectin 5.
 REPEAT 278 315 Plectin 6.
 REPEAT 316 353 Plectin 7.
 REPEAT 355 391 Plectin 8.
 REPEAT 392 429 Plectin 9.
 REPEAT 546 583 Plectin 10.
 REPEAT 603 640 Plectin 11.
 REPEAT 641 678 Plectin 12.
 REPEAT 679 716 Plectin 13.
 REPEAT 717 754 Plectin 14.
 REPEAT 758 792 Plectin 15.
 REPEAT 865 903 Plectin 16.
 REPEAT 923 960 Plectin 17.
 REPEAT 961 998 Plectin 18.
 REPEAT 999 1036 Plectin 19.
 REPEAT 1037 1074 Plectin 20.
 REPEAT 1239 1276 Plectin 21.
 REPEAT 1277 1314 Plectin 22.
 REPEAT 1315 1352 Plectin 23.
 REPEAT 1353 1390 Plectin 24.
 REPEAT 1391 1428 Plectin 25.
 REPEAT 1564 1601 Plectin 26.
 REPEAT 1602 1639 Plectin 27.
 REPEAT 1640 1677 Plectin 28.
 REPEAT 1678 1715 Plectin 29.
 REPEAT 1719 1753 Plectin 30.
 REPEAT 1890 1927 Plectin 31.
 REPEAT 1928 1965 Plectin 32.
 REPEAT 1966 2003 Plectin 33.
 REPEAT 2004 2041 Plectin 34.
 REPEAT 2042 2079 Plectin 35.
 REPEAT 2217 2259 Plectin 36.
 REPEAT 2260 2297 Plectin 37.
 REPEAT 2298 2335 Plectin 38.
 REPEAT 2336 2373 Plectin 39.
 REPEAT 2377 2411 Plectin 40.
 REPEAT 2751 2793 Plectin 41.
 REPEAT 2794 2831 Plectin 42.
 REPEAT 2832 2869 Plectin 43.
 REPEAT 2870 2907 Plectin 44.
 REPEAT 2911 2945 Plectin 45.
 REPEAT 3285 3327 Plectin 46.
 REPEAT 3328 3365 Plectin 47.
 REPEAT 3366 3403 Plectin 48.
 REPEAT 3404 3441 Plectin 49.
 REPEAT 3445 3479 Plectin 50.
 REPEAT 3819 3861 Plectin 51.
 REPEAT 3862 3899 Plectin 52.
 REPEAT 3900 3937 Plectin 53.
 REPEAT 3938 3975 Plectin 54.
 REPEAT 3979 4013 Plectin 55.
 REPEAT 4353 4395 Plectin 56.
 REPEAT 4396 4433 Plectin 57.
 REPEAT 4434 4471 Plectin 58.
 REPEAT 4472 4509 Plectin 59.
 REPEAT 4513 4547 Plectin 60.
 REPEAT 4887 4929 Plectin 61.
 REPEAT 4930 4967 Plectin 62.
 REPEAT 4968 5005 Plectin 63.
 REPEAT 5006 5043 Plectin 64.
 REPEAT 5047 5081 Plectin 65.
 MOD_RES 2422 2422 Phosphoserine.
 MOD_RES 2508 2508 Phosphoserine.
 MOD_RES 2716 2716 Phosphoserine.
 MOD_RES 2718 2718 Phosphoserine.
 MOD_RES 2956 2956 Phosphoserine.
 MOD_RES 3042 3042 Phosphoserine.
 MOD_RES 3250 3250 Phosphoserine.
 MOD_RES 3252 3252 Phosphoserine.
 MOD_RES 3490 3490 Phosphoserine.
 MOD_RES 3576 3576 Phosphoserine.
 MOD_RES 3784 3784 Phosphoserine.
 MOD_RES 3786 3786 Phosphoserine.
 MOD_RES 4024 4024 Phosphoserine.
 MOD_RES 4110 4110 Phosphoserine.
 MOD_RES 4318 4318 Phosphoserine.
 MOD_RES 4320 4320 Phosphoserine.
 MOD_RES 4558 4558 Phosphoserine.
 MOD_RES 4644 4644 Phosphoserine.
 MOD_RES 4852 4852 Phosphoserine.
 MOD_RES 4854 4854 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5090 AA 
Protein Sequence
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA SGQAQSVYAA 60
MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ QGLVGLELKE KLLAAERATT 120
GYPDPYGGEK LALFQAIGKE VVDRALGQSW LEVQLATGGL VDPAQGVLVA PEPACHQGLL 180
DRETWHKLSE LEPGTGDLRF LNPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG 240
AVSAAELLEV GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS 300
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP ELHEQLLVAE 360
QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA TGGLVCPARR LRLPLEAALR 420
CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ LLALCVTDPE TGLAFLPLSG GPRGGEPQGP 480
PFIKYSTRQA LSTATATVSV GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK 540
LAAELSATLE QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA 600
SAQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT GFIIDPKANK 660
GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI SLFQAMQKGL IVREHGIRLL 720
EAQIATGGVI DPVHSHRVPV DVAYRRGYFD QMLNLILLDP SDDTKGFFDP NTHENLTYLQ 780
LLERCVRDPE TGLYLLPLSS TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE 840
YFSEGRRRQL LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ 900
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM RQKLLGPRVA 960
LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR LKRAEGAIAG FRDPFSGKQV 1020
SVFQAMKKGL IPWEQAARLL EAQVATGGII DPTSHHHLPM PVAIQRGYVD QEMETALSSS 1080
SETFPTPDGQ GRTSYAQLLE ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD 1140
GTSLWDLLSS CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR 1200
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG VLLQPSGAKA 1260
SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV EDAVKVGLVG RELSEQLGQA 1320
ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC 1380
RLGLLDTQTS QVLTAVDKDN KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL 1440
EVDDHTAVAL RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ 1500
VVSAVTALVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG TTTVKEVAEM 1560
DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT ALVLLEAQAA TGFIIDPAEN 1620
RKLTVEEAFK AGMFGKETYV KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL 1680
LEAQIATGGI IDPVHSHRVP VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL 1740
QLLERCVEDP ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL 1800
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI RGEVTAADLF 1860
NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSDCIA GVTVPSTREV MSLHEASRKE 1920
LIPAAFATWL LEAQAATGFL LDPCTRQKLS VDEAVDVGLV NEELRERLLK AERAATGYRD 1980
PATGDTIPLF QAMQKQLIEK AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI 2040
YALISDQKHM RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW VLFPVNKAAR DSEHIDDETR 2100
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA LQTVAQLILE 2160
LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL ETGRSTTQEL MEDDRVKRYL 2220
EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR 2280
LSVEEPVPAG VVGSEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE 2340
AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL 2400
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ SVSVWELLFY 2460
REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA RAEAEAGSPR PDPREALRAA 2520
TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR EELLAEFGSG TLDLPALTRR LTAIIEEAEE 2580
APGARPQLQD ARRGPREPGP AGRGDGDSGR SQREGQGEGE TQEAAAAAAA ARRQEQTLRD 2640
ATMEVQRGQF QGRPVSVWDV LFSSYLSEAR RDELLAQHAA GALGLPDLVA VLTRVIEETE 2700
ERLSKVSFRG LRRQVSASEL HTSGILGPET LRDLAQGTKT LQEVTEMDSV KRYLEGTSCI 2760
AGVLVPAKDQ PGRQEKMSIY QAMWKGVLRP GTALVLLEAQ AATGFVIDPV RNLRLSVEEA 2820
VAAGVVGGEI QEKLLSAERA VTGYTDPYTG QQISLFQAMQ KDLIVREHGI RLLEAQIATG 2880
GVIDPVHSHR VPVDVAYRRG YFDEEMNRVL ADPSDDTKGF FDPNTHENLT YVQLLRRCVP 2940
DPDTGLYMLQ LAGRGSAVHQ LSEELRCALR DARVTPGSGA LQGQSVSVWE LLFYREVSED 3000
RRQDLLSRYR AGTLTVEELG ATLTSLLAQA QAQARAEAEA GSPRPDPREA LRAATMEVKV 3060
GRLRGRAVPV WDVLASGYVS GAAREELLAE FGSGTLDLPA LTRRLTAIIE EAEEAPGARP 3120
QLQDAWRGPR EPGPAGRGDG DSGRSQREGQ GEGETQEAAA AAAAARRQEQ TLRDATMEVQ 3180
RGQFQGRPVS VWDVLFSSYL SEARRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV 3240
SFRGLRRQVS ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP 3300
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS VEEAVAAGVV 3360
GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR EHGIRLLEAQ IATGGVIDPV 3420
HSHRVPVDVA YRRGYFDEEM NRVLADPSDD TKGFFDPNTH ENLTYVQLLR RCVPDPDTGL 3480
YMLQLAGRGS AVHQLSEELR CALRDARVTP GSGALQGQSV SVWELLFYRE VSEDRRQDLL 3540
SRYRAGTLTV EELGATLTSL LAQAQAQARA EAEAGSPRPD PREALRAATM EVKVGRLRGR 3600
AVPVWDVLAS GYVSGAAREE LLAEFGSGTL DLPALTRRLT AIIEEAEEAP GARPQLQDAW 3660
RGPREPGPAG RGDGDSGRSQ REGQGEGETQ EAAAAAAAAR RQEQTLRDAT MEVQRGQFQG 3720
RPVSVWDVLF SSYLSEARRD ELLAQHAAGA LGLPDLVAVL TRVIEETEER LSKVSFRGLR 3780
RQVSASELHT SGILGPETLR DLAQGTKTLQ EVTEMDSVKR YLEGTSCIAG VLVPAKDQPG 3840
RQEKMSIYQA MWKGVLRPGT ALVLLEAQAA TGFVIDPVRN LRLSVEEAVA AGVVGGEIQE 3900
KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGV IDPVHSHRVP 3960
VDVAYRRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYV QLLRRCVPDP DTGLYMLQLA 4020
GRGSAVHQLS EELRCALRDA RVTPGSGALQ GQSVSVWELL FYREVSEDRR QDLLSRYRAS 4080
TLTVEELGAT LTSLLAQAQA QARAEAEAGS PRPDPREALR AATMEVKVGR LRGRAVPVWD 4140
VLASGYVSRA AREELLAEFG SGTLDLPALT RRLTAIIEEA EEAPGARPQL QDAWRGPREP 4200
GPAGRGDGDS GRSQREGQGE GETQEAAAAT AAARRQEQTL RDATMEVQRG QFQGRPVSVW 4260
DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE TEERLSKVSF RGLRRQVSAS 4320
ELHTSGILGP ETLRDLAQGT KTLQEVTEMD SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS 4380
IYQAMWKGVL RPGTALVLLE AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE 4440
RAVTGYTDPY TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYR 4500
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM LQLAGRGSAV 4560
HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS EDRRQDLLSR YRAGTLTVEE 4620
LGATLTSLLA QAQAQARAEA EAGSPRPDPR EALRAATMEV KVGRLRGRAV PVWDVLASGY 4680
VSGAAREELL AEFGSGTLDL PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG 4740
DGDSGRSQRE GQGEGETQEA AAAAAAARRQ EQTLRDATME VQRGQFQGRP VSVWDVLFSS 4800
YLSEARRDEL LAQHAAGALG LPDLVAVLTR VIEETEERLS KVSFRGLRRQ VSASELHTSG 4860
ILGPETLRDL AQGTKTLQEV TEMDSVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW 4920
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEAVAAG VVGGEIQEKL LSAERAVTGY 4980
TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID PVHSHRVPVD VAYRRGYFDE 5040
EMNRVLADPS DDTKGFFDPN THENLTYLQL LQRATLDPET GLLFLSLSLQ 5090 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; NAS:UniProtKB.
 GO:0005198; F:structural molecule activity; NAS:UniProtKB. 
Interpro
 IPR001101; Plectin_repeat. 
Pfam
 PF00681; Plectin 
SMART
 SM00250; PLEC 
PROSITE
  
PRINTS