UniProt Accession

 EI2BD_HUMAN; Q9UI10; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UIQ9; Q9UJ95 

Genbank Protein ID

 AF112207; AJ011305; AJ011306; AJ011307; AJ011308; AJ011307; AJ011308; AC074117; CH471053; BC001870; BC091502 

Genbank Nucleotide ID

 AAF17195.1; CAB57260.1; CAB57261.1; CAB57304.1; CAB57304.1; CAB57305.1; CAB57305.1; AAY14843.1; EAX00591.1; AAH01870.1; AAH91502.1 

Protein Name

 Translation initiation factor eIF-2B subunit delta 

Protein Synonyms/Alias

 eIF-2B GDP-GTP exchange factor subunit delta 

Gene Name

 EIF2B4 

Gene Synonyms/Alias

 EIF2BD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
176	TRKDYGSKVSLFSHL	ubiquitination	[1]
282	NAIKFLNKEITSVGS	ubiquitination	[1, 2]
291	ITSVGSSKREEEAKS	ubiquitination	[2]
466	DPDDLQCKRGEHVAL	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. 

Sequence Annotation

 MOD_RES 86 86 Phosphothreonine.  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Initiation factor; Leukodystrophy; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 523 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:UniProtKB.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0031369; F:translation initiation factor binding; ISS:UniProtKB.
 GO:0042552; P:myelination; IMP:UniProtKB.
 GO:0032057; P:negative regulation of translational initiation in response to stress; ISS:UniProtKB.
 GO:0014003; P:oligodendrocyte development; IMP:UniProtKB.
 GO:0001541; P:ovarian follicle development; IMP:UniProtKB.
 GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.
 GO:0009408; P:response to heat; ISS:UniProtKB.
 GO:0043434; P:response to peptide hormone stimulus; ISS:UniProtKB.
 GO:0006413; P:translational initiation; IDA:UniProtKB. 

Interpro

 IPR000649; IF-2B-related. 

Pfam

 PF01008; IF-2B 

SMART

  

PROSITE

  

PRINTS