CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011638
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Platelet glycoprotein 4 
Protein Synonyms/Alias
 Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein IV; GPIV; CD36 
Gene Name
 Cd36 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
56TAFKNWVKTGTTVYRubiquitination[1]
385GFTLQFAKRLQVNILacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
 Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). 
Sequence Annotation
 REGION 93 120 Required for interaction with
 LIPID 3 3 S-palmitoyl cysteine (By similarity).
 LIPID 7 7 S-palmitoyl cysteine (By similarity).
 LIPID 464 464 S-palmitoyl cysteine (By similarity).
 LIPID 466 466 S-palmitoyl cysteine (By similarity).
 CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
 CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 235 235 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 417 417 N-linked (GlcNAc...) (Potential).
 DISULFID 243 311 By similarity.
 DISULFID 272 333 By similarity.
 DISULFID 313 322 By similarity.  
Keyword
 Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 472 AA 
Protein Sequence
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA FKNWVKTGTT 60
VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPEDH TVSFVQPNGA 120
IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ NSFVQVVLNS LIKKSKSSMF QTRSLKELLW 180
GYKDPFLSLV PYPISTTVGV FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP 240
SYCDMINGTD AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 300
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 360
HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 420
TIGDEKAEMF KTQVTGKIKL LGMVEMALLG IGVVMFVAFM ISYCACKSKN GK 472 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0008035; F:high-density lipoprotein particle binding; IDA:MGI.
 GO:0008289; F:lipid binding; ISS:BHF-UCL.
 GO:0070892; F:lipoteichoic acid receptor activity; IMP:MGI.
 GO:0030169; F:low-density lipoprotein particle binding; IMP:BHF-UCL.
 GO:0005041; F:low-density lipoprotein receptor activity; IMP:BHF-UCL.
 GO:0043277; P:apoptotic cell clearance; IMP:MGI.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0007166; P:cell surface receptor signaling pathway; IDA:BHF-UCL.
 GO:0071221; P:cellular response to bacterial lipopeptide; IMP:MGI.
 GO:0071447; P:cellular response to hydroperoxide; IMP:BHF-UCL.
 GO:0071222; P:cellular response to lipopolysaccharide; IMP:MGI.
 GO:0071223; P:cellular response to lipoteichoic acid; IDA:MGI.
 GO:0019934; P:cGMP-mediated signaling; IEA:Compara.
 GO:0030301; P:cholesterol transport; IMP:BHF-UCL.
 GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI.
 GO:0019915; P:lipid storage; IMP:BHF-UCL.
 GO:0042953; P:lipoprotein transport; IMP:BHF-UCL.
 GO:0044539; P:long-chain fatty acid import; IEA:Compara.
 GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL.
 GO:0055096; P:low-density lipoprotein particle mediated signaling; IDA:BHF-UCL.
 GO:0044130; P:negative regulation of growth of symbiont in host; IMP:MGI.
 GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0007263; P:nitric oxide mediated signal transduction; IEA:Compara.
 GO:0006910; P:phagocytosis, recognition; IDA:MGI.
 GO:0015911; P:plasma membrane long-chain fatty acid transport; IEA:Compara.
 GO:0030194; P:positive regulation of blood coagulation; IMP:BHF-UCL.
 GO:2000334; P:positive regulation of blood microparticle formation; IMP:BHF-UCL.
 GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Compara.
 GO:0010886; P:positive regulation of cholesterol storage; IMP:BHF-UCL.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:MGI.
 GO:0032735; P:positive regulation of interleukin-12 production; IMP:MGI.
 GO:0032755; P:positive regulation of interleukin-6 production; IMP:MGI.
 GO:0060907; P:positive regulation of macrophage cytokine production; IMP:MGI.
 GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IMP:BHF-UCL.
 GO:0043410; P:positive regulation of MAPK cascade; IMP:MGI.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
 GO:0060100; P:positive regulation of phagocytosis, engulfment; IDA:MGI.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:MGI.
 GO:2000121; P:regulation of removal of superoxide radicals; IMP:BHF-UCL.
 GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IC:BHF-UCL.
 GO:0035634; P:response to stilbenoid; IEP:UniProtKB. 
Interpro
 IPR002159; CD36.
 IPR005428; CD36_antigen. 
Pfam
 PF01130; CD36 
SMART
  
PROSITE
  
PRINTS
 PR01610; CD36ANTIGEN.
 PR01609; CD36FAMILY.