UniProt Accession

 FOLX_ECOLI; P0AC19; P77796; P80449 

Genbank Protein ID

 X96709; U47639; AP009048; U00096 

Genbank Nucleotide ID

 CAA65471.1; AAB47972.1; BAA16140.1; AAC75363.1 

Protein Name

 D-erythro-7,8-dihydroneopterin triphosphate epimerase 

Protein Synonyms/Alias

 Dihydroneopterin triphosphate 2'-epimerase 

Gene Name

 folX 

Gene Synonyms/Alias

 b2303; JW2300 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
22	LRTFIGIKEEEINNR	acetylation	[1]
62	LNYRTVTKNIIQHVE	acetylation	[1, 2]
102	YAEVEIDKLHALRYA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Catalyzes the epimerization of carbon 2' of the side chain of dihydroneopterin triphosphate (H2NTP) to form dihydromonapterin triphosphate (H2MTP). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 120 AA 

Protein Sequence

Gene Ontology

 GO:0004150; F:dihydroneopterin aldolase activity; IEA:InterPro.
 GO:0008719; F:dihydroneopterin triphosphate 2'-epimerase activity; IDA:EcoliWiki.
 GO:0006760; P:folic acid-containing compound metabolic process; IMP:EcoCyc. 

Interpro

 IPR006157; FolB_dom. 

Pfam

 PF02152; FolB 

SMART

 SM00905; FolB 

PROSITE

  

PRINTS