UniProt Accession

 NDK7_HUMAN; Q9Y5B8; A8K3T6; A8MY09; B3KSW9; Q5TGZ4 

Genbank Protein ID

 AF153191; AK094513; AK290701; AL031726; AL356852; Z99758; Z99758; AL031726; AL356852; AL356852; AL031726; Z99758; CH471067; CH471067; BC006983 

Genbank Nucleotide ID

 AAD34622.1; BAG52881.1; BAF83390.1; CAI18887.1; CAI18887.1; CAI18887.1; CAI22851.1; CAI22851.1; CAI22851.1; CAI19238.1; CAI19238.1; CAI19238.1; EAW90834.1; EAW90835.1; AAH06983.1 

Protein Name

 Nucleoside diphosphate kinase 7 

Protein Synonyms/Alias

 NDK 7; NDP kinase 7; nm23-H7 

Gene Name

 NME7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	SVEMHDVKNHRTFLK	ubiquitination	[1, 2]
51	RTFLKRTKYDNLHLE	ubiquitination	[1, 2, 3, 4]
65	EDLFIGNKVNVFSRQ	ubiquitination	[1, 2]
99	EKTLALIKPDAISKA	ubiquitination	[2]
105	IKPDAISKAGEIIEI	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. 

Sequence Annotation

 DOMAIN 3 91 DM10.
 ACT_SITE 206 206 Pros-phosphohistidine intermediate (By
 BINDING 99 99 ATP (By similarity).
 BINDING 145 145 ATP (By similarity).
 BINDING 193 193 ATP (By similarity).
 BINDING 203 203 ATP (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0060830; P:ciliary receptor clustering involved in smoothened signaling pathway; IEA:Compara.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0003351; P:epithelial cilium movement; IEA:Compara.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0042073; P:intraflagellar transport; IEA:Compara.
 GO:0060972; P:left/right pattern formation; IEA:Compara.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR011410; NDK7.
 IPR001564; Nucleoside_diP_kinase.
 IPR006602; Uncharacterised_DM10. 

Pfam

 PF00334; NDK 

SMART

 SM00676; DM10
 SM00562; NDK 

PROSITE

 PS51336; DM10
 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.