UniProt Accession

 NTCP4_HUMAN; Q96EP9; Q8WUZ2 

Genbank Protein ID

 AY704414; BC012048; BC019066 

Genbank Nucleotide ID

 AAW30130.1; AAH12048.2; AAH19066.1 

Protein Name

 Sodium/bile acid cotransporter 4 

Protein Synonyms/Alias

 Na(+)/bile acid cotransporter 4; Solute carrier family 10 member 4 

Gene Name

 SLC10A4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
407	EDTDISYKKLKEEEM	ubiquitination	[1, 2, 3, 4]
408	DTDISYKKLKEEEMA	ubiquitination	[3]
410	DISYKKLKEEEMADT	ubiquitination	[2, 3]
423	DTSYGTVKAENIIMM	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 CARBOHYD 6 6 N-linked (GlcNAc...) (Potential).
 CARBOHYD 18 18 N-linked (GlcNAc...) (Potential).
 CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008508; F:bile acid:sodium symporter activity; IEA:InterPro. 

Interpro

 IPR002657; BilAc/Na_symport. 

Pfam

 PF01758; SBF 

SMART

  

PROSITE

  

PRINTS