CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022946
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sedoheptulokinase 
Protein Synonyms/Alias
 SHK; Carbohydrate kinase-like protein 
Gene Name
 SHPK 
Gene Synonyms/Alias
 CARKL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
441LSRNDVLKQEVQRAFubiquitination[1, 2, 3, 4]
476LRRHLNQKES*****ubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MAARPITLGI DLGTTSVKAA LLRAAPDDPS GFAVLASCAR AARAEAAVES AVAGPQGREQ 60
DVSRILQALH ECLAALPRPQ LRSVVGIGVS GQMHGVVFWK TGQGCEWTEG GITPVFEPRA 120
VSHLVTWQDG RCSSEFLASL PQPKSHLSVA TGFGCATIFW LLKYRPEFLK SYDAAGTIHD 180
YVVAMLCGLP RPLMSDQNAA SWGYFNTQSQ SWNVETLRSS GFPVHLLPDI AEPGSVAGRT 240
SHMWFEIPKG TQVGVALGDL QASVYSCMAQ RTDAVLNIST SVQLAASMPS GFQPAQTPDP 300
TAPVAYFPYF NRTYLGVAAS LNGGNVLATF VHMLVQWMAD LGLEVEESTV YSRMIQAAVQ 360
QRDTHLTITP TVLGERHLPD QLASVTRISS SDLSLGHVTR ALCRGIVQNL HSMLPIQQLQ 420
DWGVERVMGS GSALSRNDVL KQEVQRAFPL PMSFGQDVDA AVGAALVMLR RHLNQKES 478 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050277; F:sedoheptulokinase activity; IDA:UniProtKB.
 GO:0035963; P:cellular response to interleukin-13; ISS:UniProtKB.
 GO:0071353; P:cellular response to interleukin-4; ISS:UniProtKB.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB.
 GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; ISS:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
 GO:0043030; P:regulation of macrophage activation; ISS:UniProtKB. 
Interpro
 IPR018484; Carb_kinase_FGGY_N. 
Pfam
 PF00370; FGGY_N 
SMART
  
PROSITE
 PS00933; FGGY_KINASES_1
 PS00445; FGGY_KINASES_2 
PRINTS