CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021956
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerophosphocholine phosphodiesterase GPCPD1 
Protein Synonyms/Alias
 Glycerophosphodiester phosphodiesterase 5 
Gene Name
 GPCPD1 
Gene Synonyms/Alias
 GDE5; KIAA1434 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
337TTTAQLAKVQENTIAubiquitination[1]
631VEQLERLKQELPELKacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity (By similarity). 
Sequence Annotation
 DOMAIN 1 115 CBM20.
 DOMAIN 328 620 GDPD.
 REGION 88 89 Substrate binding (Potential).
 BINDING 70 70 Substrate (Potential).
 MOD_RES 608 608 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 672 AA 
Protein Sequence
MTPSQVAFEI RGTLLPGEVF AICGSCDALG NWNPQNAVAL LPENDTGESM LWKATIVLSR 60
GVSVQYRYFK GYFLEPKTIG GPCQVIVHKW ETHLQPRSIT PLESEIIIDD GQFGIHNGVE 120
TLDSGWLTCQ TEIRLRLHYS EKPPVSITKK KLKKSRFRVK LTLEGLEEDD DDRVSPTVLH 180
KMSNSLEISL ISDNEFKCRH SQPECGYGLQ PDRWTEYSIQ TMEPDNLELI FDFFEEDLSE 240
HVVQGDALPG HVGTACLLSS TIAESGKSAG ILTLPIMSRN SRKTIGKVRV DYIIIKPLPG 300
YSCDMKSSFS KYWKPRIPLD VGHRGAGNST TTAQLAKVQE NTIASLRNAA SHGAAFVEFD 360
VHLSKDFVPV VYHDLTCCLT MKKKFDADPV ELFEIPVKEL TFDQLQLLKL THVTALKSKD 420
RKESVVQEEN SFSENQPFPS LKMVLESLPE DVGFNIEIKW ICQQRDGMWD GNLSTYFDMN 480
LFLDIILKTV LENSGKRRIV FSSFDADICT MVRQKQNKYP ILFLTQGKSE IYPELMDLRS 540
RTTPIAMSFA QFENLLGINV HTEDLLRNPS YIQEAKAKGL VIFCWGDDTN DPENRRKLKE 600
LGVNGLIYDR IYDWMPEQPN IFQVEQLERL KQELPELKSC LCPTVSRFVP SSLCGESDIH 660
VDANGIDNVE NA 672 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0047389; F:glycerophosphocholine phosphodiesterase activity; IEA:EC.
 GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:InterPro.
 GO:2001070; F:starch binding; IEA:InterPro.
 GO:0006071; P:glycerol metabolic process; IEA:InterPro.
 GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR013784; Carb-bd-like_fold.
 IPR002044; CBM_fam20.
 IPR004129; GlyceroP-diester-Pdiesterase.
 IPR013783; Ig-like_fold.
 IPR017946; PLC-like_Pdiesterase_TIM-brl. 
Pfam
 PF00686; CBM_20
 PF03009; GDPD 
SMART
 SM01065; CBM_2 
PROSITE
 PS51166; CBM20 
PRINTS