| Tag | Content |
|---|
| CPLM ID | CPLM-017792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CDK2-associated and cullin domain-containing protein 1 |
Protein Synonyms/Alias | |
Gene Name | Cacul1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 204 | SHLERVSKELQASPP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Cell cycle; Complete proteome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 377 AA |
Protein Sequence | MEESMEEEEM LTYEAMMDDQ NHNNWEAAAD SFRQPPPAPP LPPPPPPRPS SSIPDPGREL 60
PGGQLLAVHA GSMERKGPKE GLPMGPPPLP EPNGVIMMLK SCDAAAAVAK TAPAPTSSST 120
ININTSTSKF LMNVITIEDY KSTYWPKLDG AIDQLLTQSP GDYIPISYEQ IYSCVYKCVC 180
QQHSEQMYSD LIKKITSHLE RVSKELQASP PDLYIERFNI ALGQYMGALQ SIVPLFIYMN 240
KFYIETKLNR DLKDDLIKLF TEHVAEKHIY SLMPLLLEAQ STPFQVTPST MANIVKGLYT 300
LRPEWVQMAP TLFSKFIPNI LPPAVESELS EYAAQDQKLQ RELIQNGFTR GDQSRKRAGD 360
ELAYNSPSAC ASSRGYR 377 |
Gene Ontology | GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro. GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |