CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 711 
Protein Synonyms/Alias
 Zinc finger protein 6 
Gene Name
 ZNF711 
Gene Synonyms/Alias
 CMPX1; ZNF6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
224HMGNTPLKIGSDGSQubiquitination[1]
235DGSQEDAKEDGFGSEubiquitination[2]
289QSRMQREKMVYMAVKubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C. 
Sequence Annotation
 ZN_FING 383 408 C2H2-type 1.
 ZN_FING 414 436 C2H2-type 2.
 ZN_FING 476 499 C2H2-type 3.
 ZN_FING 505 527 C2H2-type 4.
 ZN_FING 533 556 C2H2-type 5.
 ZN_FING 562 584 C2H2-type 6; degenerate.
 ZN_FING 590 613 C2H2-type 7.
 ZN_FING 619 641 C2H2-type 8.
 ZN_FING 647 670 C2H2-type 9.
 ZN_FING 676 698 C2H2-type 10.
 ZN_FING 704 727 C2H2-type 11.
 ZN_FING 733 755 C2H2-type 12.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Mental retardation; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 761 AA 
Protein Sequence
MDSGGGSLGL HTPDSRMAHT MIMQDFVAGM AGTAHIDGDH IVVSVPEAVL VSDVVTDDGI 60
TLDHGLAAEV VHGPDIITET DVVTEGVIVP EAVLEADVAI EEDLEEDDGD HILTSELITE 120
TVRVPEQVFV ADLVTGPNGH LEHVVQDCVS GVDSPTMVSE EVLVTNSDTE TVIQAAGGVP 180
GSTVTIKTED DDDDDVKSTS EDYLMISLDD VGEKLEHMGN TPLKIGSDGS QEDAKEDGFG 240
SEVIKVYIFK AEAEDDVEIG GTEIVTESEY TSGHSVAGVL DQSRMQREKM VYMAVKDSSQ 300
EEDDIRDERR VSRRYEDCQA SGNTLDSALE SRSSTAAQYL QICDGINTNK VLKQKAKKRR 360
RGETRQWQTA VIIGPDGQPL TVYPCHICTK KFKSRGFLKR HMKNHPDHLM RKKYQCTDCD 420
FTTNKKVSFH NHLESHKLIN KVDKTHEFTE YTRRYREASP LSSNKLILRD KEPKMHKCKY 480
CDYETAEQGL LNRHLLAVHS KNFPHVCVEC GKGFRHPSEL KKHMRTHTGE KPYQCQYCIF 540
RCADQSNLKT HIKSKHGNNL PYKCEHCPQA FGDERELQRH LDLFQGHKTH QCPHCDHKST 600
NSSDLKRHII SVHTKDFPHK CEVCDKGFHR PSELKKHSDI HKGRKIHQCR HCDFKTSDPF 660
ILSGHILSVH TKDQPLKCKR CKRGFRQQNE LKKHMKTHTG RKIYQCEYCE YSTTDASGFK 720
RHVISIHTKD YPHRCEFCKK GFRRPSEKNQ HIMRHHKEAL M 761 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR006794; Transcrp_activ_Zfx/Zfy-dom.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2
 PF04704; Zfx_Zfy_act 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS