UniProt Accession

 SPRTN_HUMAN; Q9H040; B1AKT0; B5MEF7; Q5TE78; Q6UWW6; Q96BC5; Q96KA0 

Genbank Protein ID

 AY358611; AK027613; AK027317; AL512744; AL117352; CH471098; BC015740; BC068478 

Genbank Nucleotide ID

 AAQ88974.1; BAB55232.1; BAB55037.1; CAC21670.1; EAW69956.1; AAH15740.1; AAH68478.1 

Protein Name

 SprT-like domain-containing protein Spartan 

Protein Synonyms/Alias

 DNA damage protein targeting VCP; DVC1; Protein with SprT-like domain at the N terminus; Spartan 

Gene Name

 SPRTN 

Gene Synonyms/Alias

 C1orf124; DVC1; UNQ1880/PRO4323 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
230	KGKAKLGKEPVLAAE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. 

Sequence Annotation

 DOMAIN 45 212 SprT-like.
 ZN_FING 453 476 UBZ-type.
 MOTIF 253 261 SHP-box.
 MOTIF 325 332 PIP-box.  

Keyword

 Alternative splicing; Chromosome; Complete proteome; DNA damage; DNA repair; Metal-binding; Nucleus; Polymorphism; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 489 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; IDA:LIFEdb.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0070530; F:K63-linked polyubiquitin binding; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
 GO:0009411; P:response to UV; IDA:UniProtKB.
 GO:0019985; P:translesion synthesis; IDA:UniProtKB. 

Interpro

 IPR006640; SprT-like_domain.
 IPR006642; Znf_Rad18_put. 

Pfam

 PF10263; SprT-like 

SMART

 SM00731; SprT
 SM00734; ZnF_Rad18 

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS