UniProt Accession

 TPGS1_HUMAN; Q6ZTW0; Q96GE2 

Genbank Protein ID

 AK126170; BC009520 

Genbank Nucleotide ID

 BAC86469.1; AAH09520.1 

Protein Name

 Tubulin polyglutamylase complex subunit 1 

Protein Synonyms/Alias

 PGs1 

Gene Name

 TPGS1 

Gene Synonyms/Alias

 C19orf20 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MAAVEKRRQAVPP	ubiquitination	[1]
54	MLRAALLKVLEARPE	ubiquitination	[2, 3]
285	AAALFIAKVKPVG**	ubiquitination	[1, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). 

Sequence Annotation

 MOD_RES 266 266 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Flagellum; Microtubule; Phosphoprotein; Reference proteome; Spermatogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 290 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.
 GO:0030534; P:adult behavior; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007288; P:sperm axoneme assembly; IEA:Compara. 

Interpro

  

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SMART

  

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