CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005870
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NK-tumor recognition protein 
Protein Synonyms/Alias
 NK-TR protein; Natural-killer cells cyclophilin-related protein; Putative peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase 
Gene Name
 Nktr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
923GQSHIKAKPPAKPPTacetylation[1]
1208GKKEGAEKSQMNLTDacetylation[1]
1216SQMNLTDKWKPLQGVacetylation[1]
1249LSTVPEVKPQGLRIEubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654] 
Functional Description
 Component of a putative tumor-recognition complex. Involved in the function of NK cells. 
Sequence Annotation
 DOMAIN 10 175 PPIase cyclophilin-type.
 REGION 1303 1453 Arg/Ser tandem repeat-rich.
 MOD_RES 379 379 Phosphoserine (By similarity).
 MOD_RES 880 880 Phosphoserine (By similarity).
 MOD_RES 882 882 Phosphoserine (By similarity).
 MOD_RES 884 884 Phosphoserine (By similarity).
 MOD_RES 1139 1139 Phosphoserine.
 CROSSLNK 1249 1249 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Cyclosporin; Direct protein sequencing; Isomerase; Isopeptide bond; Phosphoprotein; Reference proteome; Repeat; Rotamase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1453 AA 
Protein Sequence
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG KTTGKKLCYK 60
GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI LKHDRAFLLS MANRGKHTNG 120
SQFFITTKPA PHLDGVHVVF GLVISGFEVI EQIENLKTDA ASRPYADVRV IDCGVLATKL 180
TKDVFEKKRK KPTCSEGSDS SSRSSSSSES SSESEVERET IRRRRHKRRP KVRHAKKRRK 240
EMSSSEEPRR KRTVSPEGYS ERSDVNEKRS VDSNTKREKP VVRPEEIPPV PENRFLLRRD 300
MPAITVEPEQ NIPDVAPVVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSH SESKDDDSSE 360
TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER SLSQRSRSWS YNGYYSDLST 420
ARHSDGHHKK HRKEKKFKHK KKAKKQKHCR RHRQTKKRRI VMPDLEPSRS PTHRMKSSCV 480
RERRSRASSS SSHHSSKRDW SKSDQDDGSA STHSSRDSYR SKSHSRSDSR GSSRSRAVSK 540
SSSRSLNRSK SRSSSRSGPR RTSISPKKPA QLSENKPVKT EPLRPSVPQN GNVLVQPVAA 600
ENIPVIPLSD SPPPSRWKPG QKPWKPSYER IQEMKAKTTH LLPVQSTYSL TNIKATVSSS 660
SYHKREKPSE SDGSAYSKYS DRSSGSSGRS GSKSSRSRSS SRSYTRSRSR SLPTSRSLSR 720
SPSSRSHSPN KYSDGSQHSR SSSYTSVSSD DGRRAMFRSN RKKSVTSHKR HRSNSEKTLH 780
SKYVRGREKS SRHRKYSESR SSLDYSSDSD QSHVQVYSAP EKEKQGKVEA LNDKQGKGRE 840
EGKPKPEWEC PRSKKRTPKD HSRDDSVSKG KNCAGSKWDS ESNSEQDVTK SRKSDPRRGS 900
EKEEGEASSD SESEVGQSHI KAKPPAKPPT STFLPGSDGA WKSRRPQSSA SESESSCSNL 960
GNIRGEPQKQ KHSKDDLKGD HTKRAREKSK AKKDKKHKAP KRKQAFHWQP PLEFGDDEEE 1020
EMNGKQVTQD PKEKRHVSEK CEAVKDGIPN VEKTCDEGSS PSKPKKGTLE QDPLAEGGHD 1080
PSSCPAPLKV EDNTASSPPS AQHLEEHGPG GGEDVLQTDD NMEICTPDRT SPAKGEVVSP 1140
LANHRLDSPE VNIIPEQDEC MAHPRAGGEQ ESSMSESKTL GESGVKQDSS TSVTSPVETS 1200
GKKEGAEKSQ MNLTDKWKPL QGVGNLSVST ATTSSALDVK ALSTVPEVKP QGLRIEIKSK 1260
NKVRPGSLFD EVRKTARLNR RPRNQESSSD DQTPSRDGDS QSRSPHRSRS KSETKSRHRT 1320
RSVSYSHSRS RSRSSTSSYR SRSYSRSRSR DWYSRGRTRS RSSSYGSFHS HRTSSRSRSR 1380
SSSYDLHSRS RSYTYDSYYS RSRSRSRSQR SDSYHRGRSY NRRSRSGRSY GSDSESDRSY 1440
SHHRSPSESS RYS 1453 
Gene Ontology
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS. 
Pfam
 PF00160; Pro_isomerase 
SMART
  
PROSITE
 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.