Tag | Content |
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CPLM ID | CPLM-014516 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Spliceosome RNA helicase Ddx39b |
Protein Synonyms/Alias | 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; DEAD box protein Uap56 |
Gene Name | Ddx39b |
Gene Synonyms/Alias | Bat1; Bat1a; Uap56 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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32 | DGTEAPAKKDVKGSY | acetylation | [1] | 162 | KKDEEVLKKNCPHIV | acetylation | [1] | 188 | RNKSLNLKHIKHFIL | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex (By similarity). |
Sequence Annotation | DOMAIN 76 249 Helicase ATP-binding. DOMAIN 261 422 Helicase C-terminal. NP_BIND 89 96 ATP (By similarity). MOTIF 45 73 Q motif. MOTIF 196 199 DECD box. MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 36 36 N6-acetyllysine (By similarity). MOD_RES 38 38 Phosphoserine (By similarity). MOD_RES 172 172 Phosphothreonine (By similarity). |
Keyword | Acetylation; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; mRNA processing; mRNA splicing; mRNA transport; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Spliceosome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 428 AA |
Protein Sequence | MAENDVDNEL LDYEDDEVET AAGADGTEAP AKKDVKGSYV SIHSSGFRDF LLKPELLRAI 60 VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV LATLQQLEPV TGQVSVLVMC 120 HTRELAFQIS KEYERFSKYM PNVKVAVFFG GLSIKKDEEV LKKNCPHIVV GTPGRILALA 180 RNKSLNLKHI KHFILDECDK MLEQLDMRRD VQEIFRMTPH EKQVMMFSAT LSKEIRPVCR 240 KFMQDPMEIF VDDETKLTLH GLQQYYVKLK DNEKNRKLFD LLDVLEFNQV VIFVKSVQRC 300 IALAQLLVEQ NFPAIAIHRG MPQEERLSRY QQFKDFQRRI LVATNLFGRG MDIERVNIAF 360 NYDMPEDSDT YLHRVARAGR FGTKGLAITF VSDENDAKIL NDVQDRFEVN ISELPDEIDI 420 SSYIEQTR 428 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0000346; C:transcription export complex; IEA:Compara. GO:0005687; C:U4 snRNP; IEA:Compara. GO:0005688; C:U6 snRNP; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004004; F:ATP-dependent RNA helicase activity; IEA:Compara. GO:0030621; F:U4 snRNA binding; IEA:Compara. GO:0017070; F:U6 snRNA binding; IEA:Compara. GO:0046784; P:intronless viral mRNA export from host nucleus; IEA:Compara. GO:0010501; P:RNA secondary structure unwinding; IEA:Compara. GO:0000245; P:spliceosomal complex assembly; IEA:Compara. |
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