CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039825
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peptidyl-prolyl cis-trans isomerase 
Protein Synonyms/Alias
  
Gene Name
 FKBP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31SSLDRKDKFSFDLGKacetylation[1]
31SSLDRKDKFSFDLGKubiquitination[2, 3]
38KFSFDLGKGEVIKAWubiquitination[2, 3, 4]
43LGKGEVIKAWDIAIAubiquitination[2]
63EVCHITCKPEYAYGSubiquitination[5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 86 AA 
Protein Sequence
MPMIGDRVFV HYTGWLLDGT KFDSSLDRKD KFSFDLGKGE VIKAWDIAIA TMKVGEVCHI 60
TCKPEYAYGS AGSPPKIPPN ATLVFE 86 
Gene Ontology
 GO:0044295; C:axonal growth cone; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0030521; P:androgen receptor signaling pathway; IEA:Compara.
 GO:0006825; P:copper ion transport; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0046661; P:male sex differentiation; IEA:Compara.
 GO:0031115; P:negative regulation of microtubule polymerization; IEA:Compara.
 GO:0030850; P:prostate gland development; IEA:Compara.
 GO:0031503; P:protein complex localization; IEA:Compara.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0006463; P:steroid hormone receptor complex assembly; IEA:Compara. 
Interpro
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS