| Tag | Content |
|---|
| CPLM ID | CPLM-021540 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CCR4-NOT transcription complex subunit 10 |
Protein Synonyms/Alias | |
Gene Name | CNOT10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 74 | TAVAEFFKSNQTTTD | ubiquitination | [1] | | 255 | SAPSLFLKSNFEYLR | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4- NOT complex. |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine. |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; RNA-mediated gene silencing; Transcription; Transcription regulation; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTS GNYDACLQHL ACLQDINKDD 60
YKIILNTAVA EFFKSNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL 120
YHLRQYTEAI SVGEKLYQFI EPFEKFAQAV CFLLVDLYIL TYQAEKALHL LAVLEKMISQ 180
GNNNKNGKNE TGNNNNKDGS NHKAESGALI EAAKSKIHQY KVRAYIQMKS LKACKREIKS 240
VMNTAGNSAP SLFLKSNFEY LRGNYRKAVK LLNSSNIAEH PGFMKTGECL RCMFWNNLGC 300
IHFAMSKHNL GIFYFKKALQ ENDNVCAQLS AGSTDPGKKF SGRPMCTLLT NKRYELLYNC 360
GIQLLHIGRP LAAFECLIEA VQVYHANPRL WLRLAECCIA ANKGTSEQET KGLPSKKGIV 420
QSIVGQGYHR KIVLASQSIQ NTVYNDGQSS AIPVASMEFA AICLRNALLL LPEEQQDPKQ 480
ENGAKNSNQL GGNTESSESS ETCSSKSHDG DKFIPAPPSS PLRKQELENL KCSILACSAY 540
VALALGDNLM ALNHADKLLQ QPKLSGSLKF LGHLYAAEAL ISLDRISDAI THLNPENVTD 600
VSLGISSNEQ DQGSDKGENE AMESSGKRAP QCYPSSVNSA RTVMLFNLGS AYCLRSEYDK 660
ARKCLHQAAS MIHPKEVPPE AILLAVYLEL QNGNTQLALQ IIKRNQLLPA VKTHSEVRKK 720
PVFQPVHPIQ PIQMPAFTTV QRK 743 |
Gene Ontology | GO:0030014; C:CCR4-NOT complex; IDA:UniProtKB. GO:0005829; C:cytosol; TAS:Reactome. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW. GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |