CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003929
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Argininosuccinate lyase 
Protein Synonyms/Alias
 ASAL; Arginosuccinase 
Gene Name
 argH 
Gene Synonyms/Alias
 b3960; JW3932 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
91IHSWVEGKLIDKVGQacetylation[1]
95VEGKLIDKVGQLGKKacetylation[1]
95VEGKLIDKVGQLGKKpupylation[2]
101DKVGQLGKKLHTGRSacetylation[1]
188SRLQDALKRLDVSPLacetylation[1]
284SSLMPQKKNPDALELacetylation[1]
319GLPLAYNKDMQEDKEacetylation[1]
400VEAIRQGKPLEDLPLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Cytoplasm; Lyase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 457 AA 
Protein Sequence
MALWGGRFTQ AADQRFKQFN DSLRFDYRLA EQDIVGSVAW SKALVTVGVL TAEEQAQLEE 60
ALNVLLEDVR ARPQQILESD AEDIHSWVEG KLIDKVGQLG KKLHTGRSRN DQVATDLKLW 120
CKDTVSELLT ANRQLQSALV ETAQNNQDAV MPGYTHLQRA QPVTFAHWCL AYVEMLARDE 180
SRLQDALKRL DVSPLGCGAL AGTAYEIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS 240
AAAIGMVHLS RFAEDLIFFN TGEAGFVELS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ 300
GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MAALVLDGIQ VKRPRCQEAA 360
QQGYANATEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK PLEDLPLSEL QKFSQVIDED 420
VYPILSLQSC LDKRAAKGGV SPQQVAQAIA FAQARLG 457 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004056; F:argininosuccinate lyase activity; IDA:EcoCyc.
 GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro. 
Interpro
 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 
Pfam
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.