UniProt Accession

 ELAV1_MOUSE; P70372; Q60745; Q78QY3 

Genbank Protein ID

 U65735; AK080365; CH466566; CH466566; U17595 

Genbank Nucleotide ID

 AAB17967.1; BAC37892.1; EDL21996.1; EDL21997.1; AAA96941.1 

Protein Name

 ELAV-like protein 1 

Protein Synonyms/Alias

 Elav-like generic protein; Hu-antigen R; HuR; MelG 

Gene Name

 Elavl1 

Gene Synonyms/Alias

 Elra; Hua 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	IGEVESAKLIRDKVA	ubiquitination	[1]
55	SAKLIRDKVAGHSLG	acetylation	[2, 3]
55	SAKLIRDKVAGHSLG	ubiquitination	[1]
72	FVNYVTAKDAERAIS	ubiquitination	[1]
92	RLQSKTIKVSYARPS	ubiquitination	[1]
104	RPSSEVIKDANLYIS	ubiquitination	[1]
120	LPRTMTQKDVEDMFS	ubiquitination	[1]
191	AANPNQNKNMALLSQ	acetylation	[3]
191	AANPNQNKNMALLSQ	ubiquitination	[1]
320	KILQVSFKTNKSHK*	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'- UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. 

Sequence Annotation

 DOMAIN 20 98 RRM 1.
 DOMAIN 106 186 RRM 2.
 DOMAIN 244 322 RRM 3.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 202 202 Phosphoserine (By similarity).
 MOD_RES 217 217 Omega-N-methylated arginine; by CARM1.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0035925; F:mRNA 3'-UTR AU-rich region binding; ISO:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.
 GO:0045727; P:positive regulation of translation; IMP:MGI. 

Interpro

 IPR006548; ELAD_HUD_SF.
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS

 PR00961; HUDSXLRNA.