CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028119
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform A 
Protein Synonyms/Alias
 Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform B; Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform D; Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform E; Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform F; FI08816p 
Gene Name
 P5CDh1 
Gene Synonyms/Alias
 CG7145-RB; CG7145; Dmel_CG7145 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
113ADKKLIEKAIKTAVEacetylation[1]
124TAVETQPKWDRVSIAacetylation[1]
385GLVCEAAKLKIGDVQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 574 AA 
Protein Sequence
MLRMMRSSSS RCSSLQQSLL KSSTRCLGSV IPDLKLKDFP IANEPILGYL KDSKERKALE 60
QALKGTASSC EDIPIVIGGK EYKTPEVRYQ VMPHDHQHKL ASFYYADKKL IEKAIKTAVE 120
TQPKWDRVSI ADRLKIWEKA ADLMATTYRQ DLNAATMLGQ SKTAIQAEID SAAELIDFIR 180
MNAYFLKEVT KYQPISENIK VTKNSLRYRG IDGFIAAVSP FNFTAIGGNL SYTPALMGNG 240
VLWKPSDTAM LSNWIIFKIM REAGVPDGVV NFVPADGPVF GDTITASPHL AGINFTGSVP 300
TFNRLWKQVG NNIDNYVNFP RLTGECGGKN FHFIHASADV ESVVTSTIRS AFEYCGQKCS 360
ACSRMYVPES LWPQIKEGLV CEAAKLKIGD VQDFSSFTSA VIDDKAFKRI TGYIEHAKKS 420
PNLEILAGGT YSDSKGYFVN PTIVLSKDPK DRIMTEEIFG PVLSIYVYKE SDLLETMKLV 480
HTSTKFALTG AVFGQDEDFV KCALQEFKMA AGNFYINDKS TGSVVGQQPF GGGRMSGTND 540
KAGGPHYILR WTSPQSIKET FVPLRDVNYP YMCE 574 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:FlyBase.
 GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0007005; P:mitochondrion organization; IMP:FlyBase.
 GO:0006561; P:proline biosynthetic process; IEA:InterPro.
 GO:0006560; P:proline metabolic process; IMP:FlyBase. 
Interpro
 IPR005931; 1-pyrroline-5-COlate_DH.
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS