| Tag | Content |
|---|
| CPLM ID | CPLM-024296 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology domain-containing family G member 3 |
Protein Synonyms/Alias | PH domain-containing family G member 3 |
Gene Name | PLEKHG3 |
Gene Synonyms/Alias | KIAA0599 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 406 | ATIPQKAKEAILEMD | ubiquitination | [1] | | 429 | CSPERLKKAWSSQDE | ubiquitination | [1] | | 941 | SLRIKSNKPVMARPP | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | |
Sequence Annotation | DOMAIN 93 272 DH.
DOMAIN 296 394 PH.
MOD_RES 76 76 Phosphoserine.
MOD_RES 576 576 Phosphoserine.
MOD_RES 577 577 Phosphoserine.
MOD_RES 618 618 Phosphoserine (By similarity).
MOD_RES 631 631 Phosphoserine.
MOD_RES 640 640 Phosphoserine.
MOD_RES 643 643 Phosphoserine.
MOD_RES 647 647 Phosphoserine.
MOD_RES 741 741 Phosphoserine.
MOD_RES 827 827 Phosphoserine.
MOD_RES 962 962 Phosphoserine.
MOD_RES 1023 1023 Phosphoserine (By similarity).
MOD_RES 1037 1037 Phosphoserine.
MOD_RES 1040 1040 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1219 AA |
Protein Sequence | MPVSTSLHQD GSQERPVSLT STTSSSGSSC DSRSAMEEPS SSEAPAKNGA GSLRSRHLPN 60
SNNNSSSWLN VKGPLSPFNS RAAAGPAHHK LSYLGRVVRE IVETERMYVQ DLRSIVEDYL 120
LKIIDTPGLL KPEQVSALFG NIENIYALNS QLLRDLDSCN SDPVAVASCF VERSQEFDIY 180
TQYCNNYPNS VAALTECMRD KQQAKFFRDR QELLQHSLPL GSYLLKPVQR ILKYHLLLQE 240
IAKHFDEEED GFEVVEDAID TMTCVAWYIN DMKRRHEHAV RLQEIQSLLI NWKGPDLTTY 300
GELVLEGTFR VHRVRNERTF FLFDKTLLIT KKRGDHFVYK GNIPCSSLML IESTRDSLCF 360
TVTHYKHSKQ QYSIQAKTVE EKRNWTHHIK RLILENHHAT IPQKAKEAIL EMDSYYPNRY 420
RCSPERLKKA WSSQDEVSTN VRQGRRQSEP TKHLLRQLNE KARAAGMKGK GRRESESSRS 480
SRRPSGRSPT STEKRMSFES ISSLPEVEPD PEAGSEQEVF SAVEGPSAEE TPSDTESPEV 540
LETQLDAHQG LLGMDPPGDM VDFVAAESTE DLKALSSEEE EEMGGAAQEP ESLLPPSVLD 600
QASVIAERFV SSFSRRSSVA QEDSKSSGFG SPRLVSRSSS VLSLEGSEKG LARHGSATDS 660
LSCQLSPEVD ISVGVATEDS PSVNGMEPPS PGCPVEPDRS SCKKKESALS TRDRLLLDKI 720
KSYYENAEHH DAGFSVRRRE SLSYIPKGLV RNSISRFNSL PRPDPEPVPP VGSKRQVGSR 780
PTSWALFELP GPSQAVKGDP PPISDAEFRP SSEIVKIWEG MESSGGSPGK GPGQGQANGF 840
DLHEPLFILE EHELGAITEE SATASPESSS PTEGRSPAHL ARELKELVKE LSSSTQGELV 900
APLHPRIVQL SHVMDSHVSE RVKNKVYQLA RQYSLRIKSN KPVMARPPLQ WEKVAPERDG 960
KSPTVPCLQE EAGEPLGGKG KRKPVLSLFD YEQLMAQEHS PPKPSSAGEM SPQRFFFNPS 1020
AVSQRTTSPG GRPSARSPLS PTETFSWPDV RELCSKYASR DEARRAGGGR PRGPPVNRSH 1080
SVPENMVEPP LSGRVGRCRS LSTKRGRGGG EAAQSPGPLP QSKPDGGETL YVTADLTLED 1140
NRRVIVMEKG PLPSPTAGLE ESSGQGPSSP VALLGQVQDF QQSAECQPKE EGSRDPADPS 1200
QQGRVRNLRE KFQALNSVG 1219 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |