CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021319
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 39S ribosomal protein L46, mitochondrial 
Protein Synonyms/Alias
 L46mt; MRP-L46; P2ECSL 
Gene Name
 MRPL46 
Gene Synonyms/Alias
 C15orf4; LIECG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
132EQKFLQFKLGARITEubiquitination[1, 2, 3]
203SENNMEAKFLGNAPCubiquitination[1, 3]
230TESNLGAKVFFFKALacetylation[4]
230TESNLGAKVFFFKALubiquitination[1, 3]
265DELGDYLKPKYLAQVacetylation[4, 5, 6]
267LGDYLKPKYLAQVRRacetylation[6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
 MOD_RES 230 230 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 279 AA 
Protein Sequence
MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS 60
KPLTPLQEEM ASLLQQIEIE RSLYSDHELR ALDENQRLAK KKADLHDEED EQDILLAQDL 120
EDMWEQKFLQ FKLGARITEA DEKNDRTSLN RKLDRNLVLL VREKFGDQDV WILPQAEWQP 180
GETLRGTAER TLATLSENNM EAKFLGNAPC GHYTFKFPQA MRTESNLGAK VFFFKALLLT 240
GDFSQAGNKG HHVWVTKDEL GDYLKPKYLA QVRRFVSDL 279 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0016787; F:hydrolase activity; IEA:InterPro. 
Interpro
 IPR015797; NUDIX_hydrolase_dom-like.
 IPR021757; Ribosomal_L46. 
Pfam
 PF11788; MRP-L46 
SMART
  
PROSITE
  
PRINTS