CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007562
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histidine ammonia-lyase 
Protein Synonyms/Alias
 Histidase 
Gene Name
 HAL 
Gene Synonyms/Alias
 HIS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158EVIDSIIKEKTVVYGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 MOD_RES 254 254 2,3-didehydroalanine (Ser) (By
 MOD_RES 631 631 Phosphoserine (By similarity).
 MOD_RES 635 635 Phosphoserine (By similarity).
 MOD_RES 648 648 Phosphoserine (By similarity).
 CROSSLNK 253 255 5-imidazolinone (Ala-Gly) (By  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Histidine metabolism; Lyase; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MPRYTVHVRG EWLAVPCQDA QLTVGWLGRE AVRRYIKNKP DNGGFTSVDD AHFLVRRCKG 60
LGLLDNEDRL EVALENNEFV EVVIEGDAMS PDFIPSQPEG VYLYSKYREP EKYIELDGDR 120
LTTEDLVNLG KGRYKIKLTP TAEKRVQKSR EVIDSIIKEK TVVYGITTGF GKFARTVIPI 180
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEMFNAS 240
CLPYVPEKGT VGASGDLAPL SHLALGLVGE GKMWSPKSGW ADAKYVLEAH GLKPVILKPK 300
EGLALINGTQ MITSLGCEAV ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHALRPHRG 360
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKNIITT 420
ELNSATDNPM VFANRGETVS GGNFHGEYPA KALDYLAIGI HELAAISERR IERLCNPSLS 480
ELPAFLVAEG GLNSGFMIAH CTAAALVSEN KALCHPSSVD SLSTSAATED HVSMGGWAAR 540
KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600
EAAHRLLLEQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LQFLHKKSTK IPESEDL 657 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004397; F:histidine ammonia-lyase activity; IEA:EC.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0006548; P:histidine catabolic process; TAS:Reactome.
 GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
 GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001106; Aromatic_Lyase.
 IPR024083; Fumarase/histidase_N.
 IPR005921; HutH.
 IPR008948; L-Aspartase-like.
 IPR022313; Phe/His_NH3-lyase_AS. 
Pfam
 PF00221; Lyase_aromatic 
SMART
  
PROSITE
 PS00488; PAL_HISTIDASE 
PRINTS