UniProt Accession

 ST1A1_RAT; P17988; Q548D2 

Genbank Protein ID

 X52883; L19998; L16241; AF394783; X68640 

Genbank Nucleotide ID

 CAA37065.1; AAA41644.1; AAK77559.1; CAA48604.1 

Protein Name

 Sulfotransferase 1A1 

Protein Synonyms/Alias

 ST1A1; Aryl sulfotransferase; Aryl sulfotransferase IV; ASTIV; Minoxidil sulfotransferase; Mx-ST; PST-1; Phenol sulfotransferase; Sulfokinase; Tyrosine-ester sulfotransferase 

Gene Name

 Sult1a1 

Gene Synonyms/Alias

 St1a1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	TPAPRLLKTHLPLSL	acetylation	[1]
118	PQSLLDQKVKVIYIA	acetylation	[1]
226	IVHHTSFKKMKENCM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. 

Sequence Annotation

 NP_BIND 44 49 PAPS (By similarity).
 NP_BIND 223 228 PAPS (By similarity).
 NP_BIND 251 255 PAPS (By similarity).
 REGION 102 104 Substrate binding (By similarity).
 ACT_SITE 104 104 Proton acceptor (By similarity).
 BINDING 126 126 PAPS (By similarity).
 BINDING 134 134 PAPS (By similarity).
 BINDING 189 189 PAPS (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 291 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0050656; F:3'-phosphoadenosine 5'-phosphosulfate binding; IDA:RGD.
 GO:0004062; F:aryl sulfotransferase activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0018960; P:4-nitrophenol metabolic process; IDA:RGD.
 GO:0006584; P:catecholamine metabolic process; IDA:RGD.
 GO:0017144; P:drug metabolic process; IDA:RGD.
 GO:0008210; P:estrogen metabolic process; IMP:RGD.
 GO:0008217; P:regulation of blood pressure; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IMP:RGD.
 GO:0051923; P:sulfation; IDA:RGD.
 GO:0006805; P:xenobiotic metabolic process; IDA:RGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS