CPLM-011488

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-011488

UniProt Accession

PDE4B_HUMAN; Q07343; O15443; Q13945; Q5TEK4; Q5TEK5; Q5TEK6

Genbank Protein ID

L12686; L20966; L20971; U85048; M97515; AK289969; AK290006; AL592285; AL109926; AL357273; AL359701; AL592285; AL109926; AL357273; AL359701; AL357273; AL109926; AL359701; AL592285; AL357273; AL109926; AL359701; AL592285; AL109926; AL357273; AL359701; AL592285; AL109926; AL359701; AL109926; AL357273; AL359701; AL592285; AL359701; AL109926; AL357273; AL592285; AL359701; AL109926; AL359701; AL109926; AL357273; AL592285; AL513493; AL590783; AL591487; CH471059; BC101480; BC105040

Genbank Nucleotide ID

AAA35643.1; AAA03589.1; AAA03593.1; AAB96381.1; AAA36426.1; BAF82658.1; BAF82695.1; CAH70626.1; CAH70626.1; CAH70626.1; CAH70626.1; CAH70628.1; CAH70628.1; CAH70628.1; CAH70628.1; CAH73002.1; CAH73002.1; CAH73002.1; CAH73002.1; CAH73004.1; CAH73004.1; CAH73004.1; CAH73004.1; CAI21749.1; CAI21749.1; CAI21749.1; CAI21749.1; CAI21750.1; CAI21750.1; CAI21751.1; CAI21751.1; CAI21751.1; CAI21751.1; CAI23099.1; CAI23099.1; CAI23099.1; CAI23099.1; CAI23100.1; CAI23100.1; CAI23101.1; CAI23101.1; CAI23101.1; CAI23101.1; EAX06524.1; AAI01481.1; AAI05041.1

Protein Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Protein Synonyms/Alias

DPDE4; PDE32

Gene Name

PDE4B

Gene Synonyms/Alias

DPDE4

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
249	VSEMASNKFKRMLNR	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Sequence Annotation

NP_BIND 406 410 cAMP.
ACT_SITE 406 406 Proton donor.
METAL 410 410 Divalent metal cation 1.
METAL 446 446 Divalent metal cation 1.
METAL 447 447 Divalent metal cation 1.
METAL 447 447 Divalent metal cation 2.
METAL 564 564 Divalent metal cation 1.
BINDING 447 447 cAMP.
BINDING 564 564 cAMP.
BINDING 615 615 cAMP.

Keyword

3D-structure; Alternative splicing; cAMP; Complete proteome; Hydrolase; Metal-binding; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

736 AA

Protein Sequence

MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL QLPPLSQRQS 60
ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG PSPGRSPLDP QASSSAGLVL 120
HATFPGHSQR RESFLYRSDS DYDLSPKAMS RNSSLPSEQH GDDLIVTPFA QVLASLRSVR 180
NNFTILTNLH GTSNKRSPAA SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR 240
SVSEMASNKF KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK 300
KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL NIFNVAGYSH 360
NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH SDVAYHNSLH AADVAQSTHV 420
LLSTPALDAV FTDLEILAAI FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL 480
AVGFKLLQEE HCDIFMNLTK KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS 540
SGVLLLDNYT DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI 600
SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN WYQSMIPQSP 660
SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS YFSSTKTLCV IDPENRDSLG 720
ETDIDIATED KSPVDT 736

Gene Ontology

GO:0071944; C:cell periphery; IEA:Compara.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005634; C:nucleus; IEA:Compara.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway.
GO:0035690; P:cellular response to drug; IEA:Compara.
GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
GO:0030593; P:neutrophil chemotaxis; IEA:Compara.
GO:0001780; P:neutrophil homeostasis; IEA:Compara.
GO:0007165; P:signal transduction; IEA:InterPro.

Interpro

IPR003607; HD/PDEase_dom.
IPR023088; PDEase.
IPR002073; PDEase_catalytic_dom.
IPR023174; PDEase_CS.

Pfam

PF00233; PDEase_I

SMART

SM00471; HDc

PROSITE

PS00126; PDEASE_I

PRINTS

PR00387; PDIESTERASE1.