UniProt Accession

 HBP1_HUMAN; O60381; B3KVB7; Q8TBM1; Q8TE93; Q96AJ2 

Genbank Protein ID

 AF182038; AK074353; AK122785; AC004492; CH471070; BC017069; BC022329 

Genbank Nucleotide ID

 AAD56225.1; BAB85059.1; BAG53729.1; AAC08317.1; EAW83392.1; AAH17069.1; AAH22329.1 

Protein Name

 HMG box-containing protein 1 

Protein Synonyms/Alias

 HMG box transcription factor 1; High mobility group box transcription factor 1 

Gene Name

 HBP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	QMPNAVQKLLLVMDK	ubiquitination	[1, 2]
23	KLLLVMDKRASGMND	ubiquitination	[2]
171	AFPHHHWKEETPVRH	acetylation	[3]
225	GTRLCFHKGSNKEWQ	ubiquitination	[2]
229	CFHKGSNKEWQDVED	ubiquitination	[2]
255	DLQMGIHKGYGSDGL	ubiquitination	[2]
297	GLLTVECKLDHPFYV	acetylation	[3]
297	GLLTVECKLDHPFYV	ubiquitination	[2]
305	LDHPFYVKNKGWSSF	acetylation	[3]
307	HPFYVKNKGWSSFYP	acetylation	[3]
398	FARSGFSKNCGSPGS	ubiquitination	[2]
416	SSNSLYAKAVKNHSS	ubiquitination	[2]
419	SLYAKAVKNHSSGTV	acetylation	[3]
419	SLYAKAVKNHSSGTV	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.
 Wang W, Pan K, Chen Y, Huang C, Zhang X.
 Nucleic Acids Res. 2012 Feb;40(3):981-95. [PMID: 21967847] 

Functional Description

 Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. 

Sequence Annotation

 DOMAIN 203 345 AXH.
 DNA_BIND 434 502 HMG box.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 514 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; NAS:UniProtKB.
 GO:0043268; P:positive regulation of potassium ion transport; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR013723; Ataxin-1_HBP1.
 IPR003652; Ataxin_AXH_dom.
 IPR009071; HMG_box_dom. 

Pfam

 PF08517; AXH
 PF00505; HMG_box 

SMART

 SM00536; AXH
 SM00398; HMG 

PROSITE

 PS51148; AXH
 PS50118; HMG_BOX_2 

PRINTS